HitPredict

Interactor 1: SMD2 (P62316)
Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)
Gene: SNRPD2

Interactor 2: PRP8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
Gene: PRPF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

The method score is based on:

Property	Details
Experiments	35271311, 28515276, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	LSM~PRP8_domainIV
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005682 - U5 snRNP and 5 others more... GO:0008380 - RNA splicing GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071005 - U2-type precatalytic spliceosome GO:0071007 - U2-type catalytic step 2 spliceosome GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	118
Hs

1	2335

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024