Protein: SPT6
Transcription elongation factor SPT6 (Chromatin elongation factor SPT6)

Gene: SPT6
Organism: Saccharomyces cerevisiae S288C
Interactions: 99
UniProt ID: P23615

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000433 - carbon catabolite repression of transcription from RNA polymerase II promoter by glucose
GO:0000791 - euchromatin
GO:0001073 - transcription antitermination factor activity, DNA binding
GO:0001178 - regulation of transcriptional start site selection at RNA polymerase II promoter

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375284

RPB1
DNA-directed RNA polymerase II subunit RPB1

15

5

Small-scale

0.761

High

619173

IWS1
Transcription factor SPN1

15

3

Small-scale

0.761

High

619117

SPT6
Transcription elongation factor SPT6

2

9

Small-scale

0.755

High

557892

RPB3
DNA-directed RNA polymerase II subunit RPB3

8

3

Small-scale

0.741

High

619120

SPT5
Transcription elongation factor SPT5

6

4

Small-scale

0.726

High

549960

CSK21
Casein kinase II subunit alpha

4

3

Small-scale

0.694

High

584658

CSK22
Casein kinase II subunit alpha'

3

7

Small-scale

0.678

High

619129

SPT16
FACT complex subunit SPT16

4

1

Small-scale

0.676

High

619160

H3
Histone H3

3

8

Small-scale

0.655

High

619169

POB3
FACT complex subunit POB3

3

2

High-throughput

0.633

High

356265

H4
Histone H4

3

6

Small-scale

0.625

High

510319

SSB1
Ribosome-associated molecular chaperone SSB1

3

7

High-throughput

0.624

High

619135

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.586

High

439977

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

1

High-throughput

0.584

High

593039

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

1

Small-scale

0.584

High

619142

RPB11
DNA-directed RNA polymerase II subunit RPB11

2

1

Small-scale

0.584

High

365827

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.571

High

619150

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.567

High

619133

SPT4
Transcription elongation factor SPT4

2

0

High-throughput

0.559

High

490392

HSP71
Heat shock protein SSA1

2

7

High-throughput

0.552

High

619174

CDC73
Cell division control protein 73

1

0

Small-scale

0.537

High

412950

KAPB
cAMP-dependent protein kinase type 2

1

1

High-throughput

0.536

High

539308

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.501

High

619128

HOG1
Mitogen-activated protein kinase HOG1

1

1

Small-scale

0.501

High

619140

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.493

High

619170

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.493

High

619144

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.486

High

619151

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

Small-scale

0.486

High

619157

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.486

High

392305

H2A2
Histone H2A.2

1

6

High-throughput

0.479

High

406803

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

482094

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

593104

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

593279

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

604651

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

619119

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

619121

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

619122

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

619123

MCM2
DNA replication licensing factor MCM2

1

1

Small-scale

0.479

High

619124

MCM4
DNA replication licensing factor MCM4

1

1

Small-scale

0.479

High

619125

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

1

Small-scale

0.479

High

619126

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

619127

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

619137

CENPA
Histone H3-like centromeric protein CSE4

1

8

High-throughput

0.479

High

619138

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.479

High

619141

PAF1
RNA polymerase II-associated protein 1

1

1

Small-scale

0.479

High

619152

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

5

High-throughput

0.479

High

619161

SEN1
Helicase SEN1

1

1

High-throughput

0.479

High

619162

MCE1
mRNA-capping enzyme subunit alpha

1

1

High-throughput

0.479

High

619163

NOP3
Serine/arginine

1

1

Small-scale

0.479

High

619166

ESP1
Separin

1

1

High-throughput

0.479

High

619167

CTK1
CTD kinase subunit alpha

1

1

Small-scale

0.479

High

619172

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

619177

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.479

High

619179

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

619180

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

140432

CET1
mRNA-capping enzyme subunit beta

1

0

High-throughput

0.458

High

420552

SPT2
Protein SPT2

1

0

Small-scale

0.458

High

602308

DPOE
DNA polymerase epsilon catalytic subunit A

1

0

Small-scale

0.458

High

605909

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

619118

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

619130

MCES
mRNA cap guanine-N7 methyltransferase

1

0

High-throughput

0.458

High

619136

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

619148

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

619149

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.458

High

619153

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

619156

RTF1
RNA polymerase-associated protein RTF1

1

0

High-throughput

0.458

High

619158

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

619168

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

619175

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

619176

SGO1
Shugoshin

1

0

High-throughput

0.458

High

619143

CSK2C
Casein kinase II subunit beta'

1

1

Small-scale

0.457

High

355358

H2B1
Histone H2B.1

1

4

High-throughput

0.445

High

449918

HSP73
Heat shock protein SSA3

1

7

High-throughput

0.445

High

493243

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

619139

SET3
SET domain-containing protein 3

1

4

High-throughput

0.445

High

619145

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

619165

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

9

High-throughput

0.445

High

407740

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

431342

LTE1
Guanine nucleotide exchange factor LTE1

1

1

High-throughput

0.437

High

619131

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

619134

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

619164

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

619178

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

419303

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

619147

DJP1
DnaJ-like protein 1

1

0

High-throughput

0.426

High

619159

SFB2
SED5-binding protein 2

1

0

High-throughput

0.279

Low

619171

POC1
Proteasome chaperone 1

1

0

High-throughput

0.269

Low

141168

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

333969

ADH2
Alcohol dehydrogenase 2

1

0

Small-scale

0.249

Low

382961

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

425779

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

485652

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.249

Low

619132

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

619154

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

619155

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

555824

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

619146

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024