HitPredict

Interactor 1: ABI2 (P62484)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0007611 - learning or memory GO:0017124 - SH3 domain binding GO:0043197 - dendritic spine GO:0061001 - regulation of dendritic spine morphogenesis GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 446 Mm			1 1730
+	Mm
		1116025 ABI1_MOUSE (1-446): 9.86e-108: 329: 61.24		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Rn
		1337546 ABI1_RAT (1-446): 1.08e-107: 328: 62.08		SHAN3_RAT (1-1730): 0: 618: 98.39
+	Hs
		1224640 ABI1_HUMAN (1-446): 3.25e-104: 320: 59.61		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Hs
		1316296 ABI2_HUMAN (1-446): 1.6e-93: 293: 79.92		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Mm
		561160 SPTN1_MOUSE (2-443): 9.46e-53: 193: 13.23		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		82760 B9EKJ1_MOUSE (2-443): 7.39e-53: 193: 13.23		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Rn
		555260 SPTN1_RAT (2-443): 8.44e-53: 193: 13.23		SHAN3_RAT (1-1730): 0: 618: 98.39
+	Hs
		1045505 SPTN1_HUMAN (2-443): 1.67e-52: 192: 13.23		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Mm
		103595 ABI2_MOUSE (1-446): 7.12e-120: 359: 100.00		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Rn
		193489 O35823_RAT (73-439): 8.2e-90: 284: 95.91		CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84
+	Rn
		1351589 ABI1_RAT (1-446): 1.08e-107: 328: 62.08		SHAN2_RAT (352-1727): 7.52e-89: 322: 35.92
+	Hs
		862037 SPTN1_HUMAN (2-443): 1.67e-52: 192: 13.23		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Mm
		82740 B9EKJ1_MOUSE (2-443): 7.39e-53: 193: 13.23		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Hs
		1021399 SPTN1_HUMAN (2-443): 1.67e-52: 192: 13.23		ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01
+	Hs
		1021703 MYO1E_HUMAN (260-441): 4.51e-34: 137: 23.98		Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21
+	Hs
		883497 MYO1E_HUMAN (260-441): 4.51e-34: 137: 23.98		RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21
+	Hs
		360612 SPTA1_HUMAN (2-443): 8.61e-47: 175: 11.77		ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35
+	Hs
		965102 SPTN1_HUMAN (2-443): 1.67e-52: 192: 13.23		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Hs
		1045573 SPTN1_HUMAN (2-443): 1.67e-52: 192: 13.23		SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37
+	Mm
		561172 SPTN1_MOUSE (2-443): 9.46e-53: 193: 13.23		ANK2_MOUSE (134-335): 6.85e-09: 63.5: 31.19