Protein: S1PR4
Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)

Gene: S1PR4
Organism: Homo sapiens
Interactions: 135
UniProt ID: O95977

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005886 - plasma membrane
GO:0006955 - immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

328324

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

20

Small-scale

0.647

High

328412

TBC24
TBC1 domain family member 24

2

2

High-throughput

0.628

High

328395

SEC12
Guanine nucleotide-exchange factor SEC12

1

4

High-throughput

0.618

High

328319

GEMI4
Gem-associated protein 4

2

1

High-throughput

0.606

High

167789

NPC1
NPC intracellular cholesterol transporter 1

1

6

High-throughput

0.536

High

179338

MRP4
ATP-binding cassette sub-family C member 4

1

3

High-throughput

0.536

High

202802

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.536

High

207866

XPOT
Exportin-T

1

11

High-throughput

0.536

High

277627

PRAF3
PRA1 family protein 3

1

6

High-throughput

0.536

High

325999

TSN15
Tetraspanin-15

1

20

High-throughput

0.536

High

328303

B3A2
Anion exchange protein 2

1

7

High-throughput

0.536

High

328305

CY24A
Cytochrome b-245 light chain

1

2

High-throughput

0.536

High

328306

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

20

High-throughput

0.536

High

328307

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

20

High-throughput

0.536

High

328308

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

20

High-throughput

0.536

High

328310

AOFB
Amine oxidase [flavin-containing] B

1

1

High-throughput

0.536

High

328312

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.536

High

328313

AGRE5
Adhesion G protein-coupled receptor E5

1

9

High-throughput

0.536

High

328315

RAB13
Ras-related protein Rab-13

1

3

High-throughput

0.536

High

328316

CAV2
Caveolin-2

1

4

High-throughput

0.536

High

328317

AT12A
Potassium-transporting ATPase alpha chain 2

1

20

High-throughput

0.536

High

328318

SYJ2B
Synaptojanin-2-binding protein

1

20

High-throughput

0.536

High

328320

CNTP1
Contactin-associated protein 1

1

5

High-throughput

0.536

High

328321

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.536

High

328322

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

1

High-throughput

0.536

High

328323

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

20

High-throughput

0.536

High

328325

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.536

High

328326

S39A6
Zinc transporter ZIP6

1

20

High-throughput

0.536

High

328327

TMED1
Transmembrane emp24 domain-containing protein 1

1

4

High-throughput

0.536

High

328329

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.536

High

328330

MSMO1
Methylsterol monooxygenase 1

1

5

High-throughput

0.536

High

328331

MICA
MHC class I polypeptide-related sequence A

1

3

High-throughput

0.536

High

328333

ANO6
Anoctamin-6

1

2

High-throughput

0.536

High

328338

GP107
Protein GPR107

1

5

High-throughput

0.536

High

328344

CNNM4
Metal transporter CNNM4

1

6

High-throughput

0.536

High

328345

S39A4
Zinc transporter ZIP4

1

20

High-throughput

0.536

High

328352

GP180
Integral membrane protein GPR180

1

3

High-throughput

0.536

High

328355

TM87A
Transmembrane protein 87A

1

5

High-throughput

0.536

High

328356

DGLB
Diacylglycerol lipase-beta

1

3

High-throughput

0.536

High

328357

ZNT7
Zinc transporter 7

1

9

High-throughput

0.536

High

328358

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

9

High-throughput

0.536

High

328360

TBC15
TBC1 domain family member 15

1

3

High-throughput

0.536

High

328365

MRP2
ATP-binding cassette sub-family C member 2

1

3

High-throughput

0.536

High

328368

GCP3
Gamma-tubulin complex component 3

1

7

High-throughput

0.536

High

328374

IPO9
Importin-9

1

13

High-throughput

0.536

High

328375

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

8

High-throughput

0.536

High

328376

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.536

High

328378

TM9S2
Transmembrane 9 superfamily member 2

1

13

High-throughput

0.536

High

328379

S29A1
Equilibrative nucleoside transporter 1

1

2

High-throughput

0.536

High

328380

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.536

High

328381

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

4

High-throughput

0.536

High

328387

TTYH3
Protein tweety homolog 3

1

10

High-throughput

0.536

High

328388

YIPF3
Protein YIPF3

1

5

High-throughput

0.536

High

328390

INT2
Integrator complex subunit 2

1

1

High-throughput

0.536

High

328391

METL9
Protein-L-histidine N-pros-methyltransferase

1

1

High-throughput

0.536

High

328392

GHITM
Growth hormone-inducible transmembrane protein

1

5

High-throughput

0.536

High

328396

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

3

High-throughput

0.536

High

328398

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

6

High-throughput

0.536

High

328400

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

3

High-throughput

0.536

High

328401

RMND1
Required for meiotic nuclear division protein 1 homolog

1

2

High-throughput

0.536

High

328405

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

6

High-throughput

0.536

High

328410

LCAP
Leucyl-cystinyl aminopeptidase

1

3

High-throughput

0.536

High

328411

S39AA
Zinc transporter ZIP10

1

20

High-throughput

0.536

High

328418

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

4

High-throughput

0.536

High

328420

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.536

High

328421

TNPO3
Transportin-3

1

14

High-throughput

0.536

High

328422

FLVC1
Heme transporter FLVCR1

1

2

High-throughput

0.536

High

328314

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

328328

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.513

High

328340

INT3
Integrator complex subunit 3

1

0

High-throughput

0.513

High

328383

SGPP1
Sphingosine-1-phosphate phosphatase 1

1

0

High-throughput

0.513

High

328394

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

0

High-throughput

0.513

High

328399

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.513

High

328406

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.513

High

328407

ATX10
Ataxin-10

1

0

High-throughput

0.513

High

175551

TM9S1
Transmembrane 9 superfamily member 1

1

13

High-throughput

0.489

High

178087

IPO8
Importin-8

1

11

High-throughput

0.489

High

199256

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.489

High

212196

ERD23
ER lumen protein-retaining receptor 3

1

3

High-throughput

0.489

High

260166

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

1

High-throughput

0.489

High

295703

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

2

High-throughput

0.489

High

318449

CDS2
Phosphatidate cytidylyltransferase 2

1

2

High-throughput

0.489

High

328304

PPAL
Lysosomal acid phosphatase

1

5

High-throughput

0.489

High

328309

ERD21
ER lumen protein-retaining receptor 1

1

3

High-throughput

0.489

High

328335

MBRL
Membralin

1

4

High-throughput

0.489

High

328336

YIF1B
Protein YIF1B

1

1

High-throughput

0.489

High

328337

NOM1
Nucleolar MIF4G domain-containing protein 1

1

1

High-throughput

0.489

High

328341

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

2

High-throughput

0.489

High

328342

RINT1
RAD50-interacting protein 1

1

3

High-throughput

0.489

High

328343

TTC27
Tetratricopeptide repeat protein 27

1

1

High-throughput

0.489

High

328346

THADA
tRNA

1

5

High-throughput

0.489

High

328347

CERS6
Ceramide synthase 6

1

14

High-throughput

0.489

High

328348

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

4

High-throughput

0.489

High

328349

MON2
Protein MON2 homolog

1

5

High-throughput

0.489

High

328350

FRMD5
FERM domain-containing protein 5

1

5

High-throughput

0.489

High

328351

NOP9
Nucleolar protein 9

1

2

High-throughput

0.489

High

328353

ZDH13
Palmitoyltransferase ZDHHC13

1

6

High-throughput

0.489

High

328354

K2013
Uncharacterized protein KIAA2013

1

5

High-throughput

0.489

High

328359

GOGA5
Golgin subfamily A member 5

1

3

High-throughput

0.489

High

328361

THEM6
Protein THEM6

1

3

High-throughput

0.489

High

328362

LMBR1
Limb region 1 protein homolog

1

2

High-throughput

0.489

High

328363

TM9S4
Transmembrane 9 superfamily member 4

1

13

High-throughput

0.489

High

328366

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

328367

YIPF5
Protein YIPF5

1

5

High-throughput

0.489

High

328369

F241B
Protein FAM241B

1

6

High-throughput

0.489

High

328370

SAAL1
Protein SAAL1

1

2

High-throughput

0.489

High

328371

CERS2
Ceramide synthase 2

1

14

High-throughput

0.489

High

328372

RN185
E3 ubiquitin-protein ligase RNF185

1

7

High-throughput

0.489

High

328373

MBOA7
Lysophospholipid acyltransferase 7

1

7

High-throughput

0.489

High

328377

SGMR1
Sigma non-opioid intracellular receptor 1

1

6

High-throughput

0.489

High

328382

PTSS2
Phosphatidylserine synthase 2

1

6

High-throughput

0.489

High

328384

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.489

High

328385

FUT8
Alpha-(1,6)-fucosyltransferase

1

1

High-throughput

0.489

High

328389

DERL2
Derlin-2

1

4

High-throughput

0.489

High

328393

AT133
Polyamine-transporting ATPase 13A3

1

20

High-throughput

0.489

High

328397

TM9S3
Transmembrane 9 superfamily member 3

1

13

High-throughput

0.489

High

328403

TM160
Transmembrane protein 160

1

2

High-throughput

0.489

High

328404

T161A
Transmembrane protein 161A

1

5

High-throughput

0.489

High

328408

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.489

High

328409

IPO11
Importin-11

1

12

High-throughput

0.489

High

328413

TMCO1
Calcium load-activated calcium channel

1

3

High-throughput

0.489

High

328414

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.489

High

328415

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

8

High-throughput

0.489

High

328416

MAN1
Inner nuclear membrane protein Man1

1

2

High-throughput

0.489

High

328419

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

1

High-throughput

0.489

High

328423

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

6

High-throughput

0.489

High

175412

SIVA
Apoptosis regulatory protein Siva

1

1

Small-scale

0.479

High

328334

Q4LE69
1-phosphatidylinositol 4-kinase

1

9

High-throughput

0.479

High

328311

PI4KA
Phosphatidylinositol 4-kinase alpha

1

10

High-throughput

0.445

High

328332

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

0

High-throughput

0.279

Low

328339

TBC9B
TBC1 domain family member 9B

1

0

High-throughput

0.279

Low

328364

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.279

Low

328386

OSBL8
Oxysterol-binding protein-related protein 8

1

0

High-throughput

0.279

Low

328402

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.279

Low

328417

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024