HitPredict

Interactor 1: RPB7 (P62487)
DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)
Gene: POLR2G

Interactor 2: TF2B (Q00403)
Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)
Gene: GTF2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	26496610, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	S1~TF_Zn_Ribbon
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006366 - transcription by RNA polymerase II GO:0006367 - transcription initiation at RNA polymerase II promoter
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 172 Hs			1 316
+	Sc
		661815 RPB7_YEAST (1-171): 4.45e-63: 193: 42.78		TF2B_YEAST (13-314): 1.08e-103: 308: 33.54
+	Sc
		661867 RPC8_YEAST (1-158): 1.07e-49: 160: 19.39		TF2B_YEAST (13-314): 1.08e-103: 308: 33.54
+	Sc
		663841 RPC8_YEAST (1-158): 1.07e-49: 160: 19.39		TF3B_YEAST (15-306): 9.45e-89: 278: 21.41
+	Sp
		292882 RPC8_SCHPO (1-158): 1.31e-50: 162: 24.26		TF3B_SCHPO (13-305): 1.32e-87: 272: 20.88