Protein: AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)

Gene: AGAP1
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q9UPQ3

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005525 - GTP binding
GO:0005543 - phospholipid binding
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

975324

ARF6
ADP-ribosylation factor 6

3

17

Small-scale

0.834

High

1014982

ARF1
ADP-ribosylation factor 1

2

17

Small-scale

0.799

High

962640

RHOA
Transforming protein RhoA

1

20

Small-scale

0.724

High

1147465

EPHA7
Ephrin type-A receptor 7

2

10

High-throughput

0.705

High

1460024

RSP14
Radial spoke head 14 homolog

2

1

High-throughput

0.700

High

1399427

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

13

High-throughput

0.691

High

1034932

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

Small-scale

0.676

High

1411859

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

2

High-throughput

0.656

High

955759

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.647

High

988830

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

1462521

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

15

Small-scale

0.647

High

1116138

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.625

High

1421090

TANC1
Protein TANC1

1

5

High-throughput

0.618

High

1438857

TANC2
Protein TANC2

1

5

High-throughput

0.618

High

1462524

E41L3
Band 4.1-like protein 3

1

7

High-throughput

0.618

High

208759

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

7

High-throughput

0.618

High

269635

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

8

High-throughput

0.618

High

374284

RASN
GTPase NRas

1

20

High-throughput

0.618

High

376101

RASK
GTPase KRas

1

20

High-throughput

0.618

High

637979

NF1
Neurofibromin

1

20

High-throughput

0.618

High

941859

ARL4C
ADP-ribosylation factor-like protein 4C

1

20

High-throughput

0.618

High

1145175

RAB35
Ras-related protein Rab-35

1

13

High-throughput

0.618

High

1187149

TBC25
TBC1 domain family member 25

1

4

High-throughput

0.618

High

1219642

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.618

High

1256113

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

1257056

SYDE1
Rho GTPase-activating protein SYDE1

1

10

High-throughput

0.618

High

1309265

KSR1
Kinase suppressor of Ras 1

1

15

High-throughput

0.618

High

1352624

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.618

High

1357446

DEP1B
DEP domain-containing protein 1B

1

7

High-throughput

0.618

High

1420077

KPCD2
Serine/threonine-protein kinase D2

1

18

High-throughput

0.618

High

1460600

NGAP
Ras GTPase-activating protein nGAP

1

20

High-throughput

0.618

High

1461587

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.618

High

1338849

FLCN
Folliculin

2

3

High-throughput

0.611

High

1260594

ZN534
Zinc finger protein 534

2

1

High-throughput

0.606

High

1348995

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.601

High

1324716

MIER2
Mesoderm induction early response protein 2

3

3

High-throughput

0.599

High

1278596

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

3

High-throughput

0.593

High

1126669

GRB7
Growth factor receptor-bound protein 7

1

20

High-throughput

0.587

High

1400877

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.586

High

1412894

RTKN
Rhotekin

1

0

High-throughput

0.586

High

557529

SRC
Proto-oncogene tyrosine-protein kinase Src

1

16

Small-scale

0.579

High

397231

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

1330149

PCD20
Protocadherin-20

2

10

High-throughput

0.558

High

1411376

LZTS2
Leucine zipper putative tumor suppressor 2

2

7

High-throughput

0.558

High

1462211

PCDAC
Protocadherin alpha-12

2

5

High-throughput

0.558

High

173559

XPO1
Exportin-1

1

4

High-throughput

0.553

High

176898

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

High-throughput

0.553

High

230593

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.553

High

245290

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

12

High-throughput

0.553

High

710575

EPHA2
Ephrin type-A receptor 2

1

9

High-throughput

0.553

High

831656

CCNF
Cyclin-F

1

3

High-throughput

0.553

High

845863

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.553

High

936486

AFAD
Afadin

1

20

High-throughput

0.553

High

1025607

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.553

High

1092517

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

17

High-throughput

0.553

High

1129996

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.553

High

1216039

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

3

High-throughput

0.553

High

1216109

SPD2A
SH3 and PX domain-containing protein 2A

1

20

High-throughput

0.553

High

1229912

AN34A
Ankyrin repeat domain-containing protein 34A

1

12

High-throughput

0.553

High

1235032

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.553

High

1286564

PHLB2
Pleckstrin homology-like domain family B member 2

1

5

High-throughput

0.553

High

1401139

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

14

High-throughput

0.553

High

1402229

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.553

High

1437685

PKHA5
Pleckstrin homology domain-containing family A member 5

1

14

High-throughput

0.553

High

1447282

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.553

High

1454254

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.553

High

1459751

LIMA1
LIM domain and actin-binding protein 1

1

11

High-throughput

0.553

High

1460302

XPO7
Exportin-7

1

4

High-throughput

0.553

High

1462522

GAB2
GRB2-associated-binding protein 2

1

10

High-throughput

0.553

High

1307366

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

2

High-throughput

0.536

High

1382552

TRI52
E3 ubiquitin-protein ligase TRIM52

1

3

High-throughput

0.536

High

1409803

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.517

High

1454076

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.517

High

255299

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.514

High

935298

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.514

High

1433655

E41L1
Band 4.1-like protein 1

1

8

High-throughput

0.514

High

155215

NCKP5
Nck-associated protein 5

1

10

High-throughput

0.489

High

209357

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

6

High-throughput

0.489

High

691540

1433T
14-3-3 protein theta

1

20

High-throughput

0.489

High

718487

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.489

High

730354

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.489

High

967026

1433G
14-3-3 protein gamma

1

20

High-throughput

0.489

High

972134

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.489

High

990873

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.489

High

1049910

1433F
14-3-3 protein eta

1

20

High-throughput

0.489

High

1259080

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

1

High-throughput

0.489

High

1310527

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

1431484

CAD23
Cadherin-23

1

5

High-throughput

0.489

High

405564

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

243301

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

941094

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

1108289

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1134088

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

423466

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

281458

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

1065787

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

6

High-throughput

0.437

High

1338127

NAV1
Neuron navigator 1

1

6

High-throughput

0.437

High

1349486

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1360420

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.437

High

1410268

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

1460944

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.437

High

1461672

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.437

High

1462526

KCTD3
BTB/POZ domain-containing protein KCTD3

1

7

High-throughput

0.437

High

1462527

PCDAA
Protocadherin alpha-10

1

5

High-throughput

0.437

High

530589

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.407

High

591395

CD44
CD44 antigen

1

1

High-throughput

0.407

High

1145440

RNPS1
RNA-binding protein with serine-rich domain 1

1

2

High-throughput

0.407

High

1258616

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.407

High

1394903

EAF1
ELL-associated factor 1

1

2

High-throughput

0.407

High

1462523

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.407

High

920724

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

0

High-throughput

0.279

Low

926245

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.279

Low

1160618

SMN
Survival motor neuron protein

1

0

High-throughput

0.265

Low

252194

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.249

Low

339121

NADK
NAD kinase

1

0

High-throughput

0.249

Low

719282

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.249

Low

1390427

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

1452554

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1454715

CING
Cingulin

1

0

High-throughput

0.249

Low

1462525

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025