HitPredict

Interactor 1: E7ERP6 (E7ERP6)
NCK adaptor protein 2
Gene: NCK2

Interactor 2: WASL (O00401)
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Gene: WASL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	26871637
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 83 Hs			1 505
+	Hs
		203208 NCK1_HUMAN (1-76): 3.13e-33: 118: 78.95		SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85
+	Hs
		166030 NCK1_HUMAN (1-76): 3.13e-33: 118: 78.95		SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85
+	Hs
		203198 LCK_HUMAN (3-83): 2.29e-26: 101: 32.53		SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85
+	Hs
		166024 FYN_HUMAN (6-82): 7.11e-28: 105: 30.00		SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85
+	Mm
		435880 HCK_MOUSE (2-83): 1.5e-29: 110: 34.52		WASP_MOUSE (16-487): 4.45e-46: 170: 39.21
+	Mm
		763384 FYN_MOUSE (6-82): 7.26e-28: 105: 30.00		WASP_MOUSE (16-487): 4.45e-46: 170: 39.21
+	Mm
		411923 LCK_MOUSE (3-83): 2.11e-26: 101: 32.53		WASP_MOUSE (16-487): 4.45e-46: 170: 39.21
+	Hs
		557631 NCK1_HUMAN (1-76): 3.13e-33: 118: 78.95		WASP_HUMAN (16-313): 7.4e-38: 147: 44.41
+	Hs
		442791 HCK_HUMAN (2-83): 1.07e-30: 114: 34.52		WASP_HUMAN (16-313): 7.4e-38: 147: 44.41
+	Hs
		454805 FGR_HUMAN (6-83): 2.13e-28: 107: 29.63		WASP_HUMAN (16-313): 7.4e-38: 147: 44.41
+	Hs
		412072 FYN_HUMAN (6-82): 7.11e-28: 105: 30.00		WASP_HUMAN (16-313): 7.4e-38: 147: 44.41
+	Hs
		126909 NCK1_HUMAN (1-76): 3.13e-33: 118: 78.95		WASL_HUMAN (378-485): 2.86e-29: 122: 100.00
+	Hs
		297808 LYN_HUMAN (3-83): 2.85e-28: 107: 28.92		K0754_HUMAN (143-499): 5.78e-32: 132: 13.08
+	Hs
		126898 LCK_HUMAN (3-83): 2.29e-26: 101: 32.53		WASL_HUMAN (378-485): 2.86e-29: 122: 100.00
+	Hs
		412411 FYN_HUMAN (6-82): 7.11e-28: 105: 30.00		DYN3_HUMAN (281-367): 4.37e-18: 89.6: 29.79
+	Hs
		557740 NCK1_HUMAN (1-76): 3.13e-33: 118: 78.95		MINK1_HUMAN (269-432): 1.39e-11: 69.2: 22.16
+	Hs
		433891 LYN_HUMAN (3-83): 2.85e-28: 107: 28.92		MINK1_HUMAN (269-432): 1.39e-11: 69.2: 22.16
+	Hs
		412362 FYN_HUMAN (6-82): 7.11e-28: 105: 30.00		MAGE1_HUMAN (139-488): 1.2e-09: 62.8: 11.05
+	Hs
		433560 LYN_HUMAN (3-83): 2.85e-28: 107: 28.92		MUC1_HUMAN (125-417): 5.85e-09: 60.8: 8.19
+	Hs
		411582 LCK_HUMAN (3-83): 2.29e-26: 101: 32.53		MUC1_HUMAN (125-417): 5.85e-09: 60.8: 8.19