HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0030334 - regulation of cell migration GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1332
+	Hs
		925434 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		545493 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Mm
		925783 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		TNIK_MOUSE (1-1332): 0: 1112: 62.60
+	Hs
		916061 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324783 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324776 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324732 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		925356 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MRCKG_HUMAN (6-1299): 0: 652: 16.34
+	Hs
		925384 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		900617 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		915778 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		545461 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		900884 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SLK_HUMAN (20-809): 1.86e-122: 413: 22.98
+	Hs
		915964 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SLK_HUMAN (20-809): 1.86e-122: 413: 22.98
+	Hs
		925309 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		M3K11_HUMAN (26-779): 1.45e-120: 397: 21.38
+	Hs
		545402 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		M3K11_HUMAN (26-779): 1.45e-120: 397: 21.38
+	Hs
		925212 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		M3K10_HUMAN (21-845): 1.48e-113: 381: 19.26
+	Ce
		104466 G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72		Q304D8_CAEEL (13-370): 2.17e-116: 372: 38.61
+	Hs
		925763 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		916098 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60