HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0006886 - intracellular protein transport GO:0007015 - actin filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 986
+	Hs
		925497 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Hs
		855782 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46
+	Hs
		925289 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHG6_HUMAN (22-797): 1.34e-103: 343: 11.48
+	Hs
		925527 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SPT13_HUMAN (22-648): 3.96e-103: 338: 11.95
+	Hs
		925271 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Gg
		1141019 Q6LC82_CHICK (1-196): 2.37e-79: 236: 55.10		ARHG6_CHICK (32-797): 2.31e-98: 328: 11.67
+	Rn
		88818 RAC1_RAT (1-196): 2.37e-79: 236: 55.10		D3ZWV8_RAT (17-814): 8.65e-94: 328: 16.93
+	Mm
		925795 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		TIAM1_MOUSE (14-814): 6.59e-94: 328: 16.87
+	Hs
		156397 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		RGRF2_HUMAN (44-864): 9.37e-94: 325: 12.43
+	Hs
		925622 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PKHG2_HUMAN (134-977): 1.16e-91: 321: 13.07
+	Ce
		975575 RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57		VAV_CAEEL (35-839): 2.53e-91: 315: 12.97
+	Hs
		167081 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18
+	Hs
		925241 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Hs
		548678 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		VAV_HUMAN (142-680): 1.01e-84: 293: 15.54
+	Hs
		925649 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHG4_HUMAN (72-648): 7.86e-86: 292: 12.85
+	Hs
		925320 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PKHG6_HUMAN (136-831): 1.36e-83: 289: 18.10
+	Hs
		224711 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		KALRN_HUMAN (224-886): 6.14e-74: 270: 11.89
+	Hs
		279854 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		TRIO_HUMAN (224-927): 2.52e-66: 246: 12.28
+	Sc
		419716 RHO1_YEAST (3-186): 1.7e-88: 260: 67.39		ROM2_YEAST (207-506): 2.12e-55: 212: 19.94
+	Hs
		925512 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHGQ_HUMAN (203-617): 3.19e-50: 193: 18.04