Protein: HMGA2
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)

Gene: HMGA2
Organism: Homo sapiens
Interactions: 127
UniProt ID: P52926

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000228 - nuclear chromosome
GO:0000976 - transcription cis-regulatory region binding
GO:0001673 - male germ cell nucleus
GO:0001837 - epithelial to mesenchymal transition

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

557977

XRCC6
X-ray repair cross-complementing protein 6

3

2

Small-scale

0.671

High

601604

HMGA1
High mobility group protein HMG-I/HMG-Y

3

0

High-throughput

0.613

High

283049

PSIP1
PC4 and SFRS1-interacting protein

2

2

Small-scale

0.611

High

487122

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.611

High

595357

H15
Histone H1.5

2

7

High-throughput

0.601

High

915425

H31
Histone H3.1

2

3

High-throughput

0.584

High

442646

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.578

High

446796

NPM
Nucleophosmin

2

0

Small-scale

0.577

High

915428

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.561

High

915471

KAT2B
Histone acetyltransferase KAT2B

1

2

Small-scale

0.561

High

915477

ANM6
Protein arginine N-methyltransferase 6

1

1

Small-scale

0.561

High

371538

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

915457

E4F1
Transcription factor E4F1

1

0

Small-scale

0.554

High

413459

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

250516

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

Small-scale

0.536

High

626131

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.536

High

132456

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.536

High

142511

IMA3
Importin subunit alpha-3

1

1

High-throughput

0.536

High

340857

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

2

High-throughput

0.536

High

593063

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.536

High

625261

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

915424

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

915452

H2A2C
Histone H2A type 2-C

1

5

High-throughput

0.536

High

915468

VRK3
Serine/threonine-protein kinase VRK3

1

3

High-throughput

0.536

High

915472

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.536

High

915492

PARP2
Poly [ADP-ribose] polymerase 2

1

3

High-throughput

0.536

High

915495

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.536

High

915497

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.529

High

915462

SYDE1
Rho GTPase-activating protein SYDE1

2

1

High-throughput

0.521

High

542397

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.515

High

915422

H4
Histone H4

1

1

Small-scale

0.515

High

915445

NUMA1
Nuclear mitotic apparatus protein 1

1

2

Small-scale

0.515

High

915489

DUX4
Double homeobox protein 4

1

1

High-throughput

0.515

High

915494

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.513

High

787949

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

892531

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

915430

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

915433

SP2
Transcription factor Sp2

1

0

High-throughput

0.513

High

915436

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

915438

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

0

High-throughput

0.513

High

915441

TOP3A
DNA topoisomerase 3-alpha

1

0

High-throughput

0.513

High

915465

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.513

High

915470

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

1

0

High-throughput

0.513

High

697052

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.501

High

915435

TF65
Transcription factor p65

1

2

Small-scale

0.501

High

915448

PCBP2
Poly(rC)-binding protein 2

1

2

Small-scale

0.501

High

363017

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.500

High

640131

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.500

High

915447

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

603214

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.480

High

687362

PTBP1
Polypyrimidine tract-binding protein 1

1

0

Small-scale

0.480

High

761194

RYK
Tyrosine-protein kinase RYK

1

0

High-throughput

0.479

High

135115

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.479

High

179168

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

1

Small-scale

0.479

High

181868

SMAD9
Mothers against decapentaplegic homolog 9

1

3

Small-scale

0.479

High

277612

H2AY
Core histone macro-H2A.1

1

7

Small-scale

0.479

High

473874

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

481173

HMGB1
High mobility group protein B1

1

4

Small-scale

0.479

High

521598

H14
Histone H1.4

1

7

Small-scale

0.479

High

536806

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

559278

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

596006

H12
Histone H1.2

1

7

Small-scale

0.479

High

634373

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

674115

BRD2
Bromodomain-containing protein 2

1

4

Small-scale

0.479

High

687168

HMGB2
High mobility group protein B2

1

4

Small-scale

0.479

High

837478

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

Small-scale

0.479

High

853947

KI67
Proliferation marker protein Ki-67

1

4

Small-scale

0.479

High

908346

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.479

High

915423

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

915427

H33
Histone H3.3

1

3

High-throughput

0.479

High

915429

RUNX1
Runt-related transcription factor 1

1

1

Small-scale

0.479

High

915437

SSRP1
FACT complex subunit SSRP1

1

4

Small-scale

0.479

High

915439

CBX3
Chromobox protein homolog 3

1

3

Small-scale

0.479

High

915444

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

Small-scale

0.479

High

915449

SMAD1
Mothers against decapentaplegic homolog 1

1

3

Small-scale

0.479

High

915451

B2LA1
Bcl-2-related protein A1

1

1

Small-scale

0.479

High

915463

H32
Histone H3.2

1

3

Small-scale

0.479

High

915464

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.479

High

915469

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.479

High

915473

H2A1C
Histone H2A type 1-C

1

5

Small-scale

0.479

High

915474

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.479

High

915475

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

Small-scale

0.479

High

915478

SMAD5
Mothers against decapentaplegic homolog 5

1

3

Small-scale

0.479

High

915479

H2A1J
Histone H2A type 1-J

1

5

Small-scale

0.479

High

915480

H2B1L
Histone H2B type 1-L

1

2

Small-scale

0.479

High

915481

VRK1
Serine/threonine-protein kinase VRK1

1

3

High-throughput

0.479

High

915485

ASXL3
Putative Polycomb group protein ASXL3

1

4

High-throughput

0.479

High

915486

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

915491

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

1

High-throughput

0.479

High

915496

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

168215

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.458

High

171855

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

344900

WIZ
Protein Wiz

1

0

Small-scale

0.458

High

600274

ZNF24
Zinc finger protein 24

1

0

Small-scale

0.458

High

904489

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

915426

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

915431

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

915443

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

Small-scale

0.458

High

915446

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

915450

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

915453

BOREA
Borealin

1

0

Small-scale

0.458

High

915454

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

Small-scale

0.458

High

915458

CDCA2
Cell division cycle-associated protein 2

1

0

Small-scale

0.458

High

915466

POGZ
Pogo transposable element with ZNF domain

1

0

Small-scale

0.458

High

915476

Z512B
Zinc finger protein 512B

1

0

Small-scale

0.458

High

915482

PCGF1
Polycomb group RING finger protein 1

1

0

High-throughput

0.458

High

915483

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

915490

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

915493

TPX2
Targeting protein for Xklp2

1

0

Small-scale

0.458

High

710137

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.457

High

529396

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

591551

H2AX
Histone H2AX

1

7

High-throughput

0.445

High

915440

ATM
Serine-protein kinase ATM

1

1

High-throughput

0.445

High

915456

H37
Histone H3-7

1

3

High-throughput

0.445

High

915459

DUX4C
Double homeobox protein 4C

1

1

High-throughput

0.445

High

915460

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

915488

RBP17
Ran-binding protein 17

1

0

High-throughput

0.279

Low

915432

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

0

High-throughput

0.261

Low

272005

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

590842

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

915434

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

915442

CD166
CD166 antigen

1

0

High-throughput

0.249

Low

915455

RHG21
Rho GTPase-activating protein 21

1

0

High-throughput

0.249

Low

915461

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

915467

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

915484

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

Small-scale

0.249

Low

915487

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025