HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	26949039
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030154 - cell differentiation GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 975
+	Hs
		925520 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		900802 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		915895 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		545560 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		436457 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		951237 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808080 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125349 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125308 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125330 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125135 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125100 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125372 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		925397 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		925423 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		HACE1_HUMAN (463-968): 7.94e-168: 516: 33.53
+	Mm
		56825 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		SMUF2_MOUSE (21-324): 1.92e-29: 128: 22.56
+	Hs
		900929 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		915987 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		900923 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Rn
		88544 RHOA_RAT (1-196): 3.27e-78: 233: 83.16		D3ZCF5_RAT (37-365): 1.89e-21: 102: 15.73