HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: H2A2B (Q8IUE6)
Histone H2A type 2-B (H2A-clustered histone 21)
Gene: H2AC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	27248496, 30021884, 33961781, 37071682
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone, CENP-T_C~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 130
+	Hs
		391638 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1B_HUMAN (1-130): 1e-67: 202: 93.85
+	Hs
		470324 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1_HUMAN (1-130): 8.04e-68: 202: 94.62
+	Hs
		594838 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1D_HUMAN (1-130): 9.47e-68: 202: 93.85
+	Hs
		917438 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2A_HUMAN (1-130): 5.07e-68: 202: 94.62
+	Hs
		917496 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A3_HUMAN (1-130): 6.67e-68: 202: 94.62
+	Hs
		917699 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1C_HUMAN (1-130): 5.24e-68: 202: 95.39
+	Hs
		917757 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1H_HUMAN (1-128): 7.7e-68: 202: 95.31
+	Hs
		917817 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1J_HUMAN (1-128): 6.6e-68: 202: 95.31
+	Hs
		917354 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2C_HUMAN (1-127): 3.2e-67: 200: 96.06
+	Hs
		555395 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Dm
		950379 H4_DROME (1-103): 4.51e-48: 150: 99.03		H2A_DROME (17-122): 2.2e-58: 178: 93.40
+	Sc
		356148 H4_YEAST (18-103): 6.13e-41: 132: 90.70		H2A2_YEAST (16-121): 8.79e-53: 164: 83.96