Protein: WDR74
WD repeat-containing protein 74 (NOP seven-associated protein 1)

Gene: WDR74
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q6RFH5

Gene Ontology (top 5):
GO:0001825 - blastocyst formation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006364 - rRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

833421

RGS2
Regulator of G-protein signaling 2

2

4

High-throughput

0.801

High

975762

RL7A
Large ribosomal subunit protein eL8

1

11

High-throughput

0.691

High

984443

RL30
Large ribosomal subunit protein eL30

1

4

High-throughput

0.691

High

1247267

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

1

High-throughput

0.691

High

1247290

PDCL3
Phosducin-like protein 3

1

4

High-throughput

0.691

High

1247298

IBTK
Inhibitor of Bruton tyrosine kinase

1

10

High-throughput

0.691

High

1023021

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

2

10

High-throughput

0.659

High

1247279

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.656

High

372350

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.640

High

1247288

MAK16
Protein MAK16 homolog

2

4

High-throughput

0.628

High

876027

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.618

High

881991

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.618

High

1007093

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.618

High

1247285

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.618

High

251777

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

11

High-throughput

0.618

High

1016962

H33
Histone H3.3

1

15

High-throughput

0.618

High

1085504

ARHG5
Rho guanine nucleotide exchange factor 5

1

13

High-throughput

0.618

High

1121038

BOP1
Ribosome biogenesis protein BOP1

1

20

Small-scale

0.618

High

1247293

ANLN
Anillin

1

3

High-throughput

0.618

High

1247297

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

14

High-throughput

0.618

High

1247265

CCNJL
Cyclin-J-like protein

2

9

High-throughput

0.611

High

288678

NPM3
Nucleoplasmin-3

2

8

High-throughput

0.601

High

1037221

H11
Histone H1.1

2

12

High-throughput

0.601

High

1247302

CARD8
Caspase recruitment domain-containing protein 8

2

0

High-throughput

0.585

High

161480

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.575

High

1226906

A16L1
Autophagy-related protein 16-1

1

18

High-throughput

0.553

High

1247281

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.549

High

140965

NOP56
Nucleolar protein 56

1

9

High-throughput

0.536

High

191682

MAGB2
Melanoma-associated antigen B2

1

9

High-throughput

0.536

High

287027

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

20

High-throughput

0.536

High

428823

RLA0
Large ribosomal subunit protein uL10

1

11

High-throughput

0.536

High

447132

NPM
Nucleophosmin

1

8

High-throughput

0.536

High

476728

RSSA
Small ribosomal subunit protein uS2

1

4

High-throughput

0.536

High

521762

H14
Histone H1.4

1

12

High-throughput

0.536

High

593400

PGFRA
Platelet-derived growth factor receptor alpha

1

12

High-throughput

0.536

High

615839

RL17
Large ribosomal subunit protein uL22

1

6

High-throughput

0.536

High

686221

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.536

High

785238

RL4
Large ribosomal subunit protein uL4

1

7

High-throughput

0.536

High

788690

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

824199

RL13A
Large ribosomal subunit protein uL13

1

9

High-throughput

0.536

High

842411

RL35
Large ribosomal subunit protein uL29

1

3

High-throughput

0.536

High

854121

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.536

High

985725

RL11
Large ribosomal subunit protein uL5

1

5

High-throughput

0.536

High

1016063

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.536

High

1099126

SRSF5
Serine/arginine-rich splicing factor 5

1

19

High-throughput

0.536

High

1099401

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.536

High

1157524

PKN2
Serine/threonine-protein kinase N2

1

9

High-throughput

0.536

High

1198578

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.536

High

1247275

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

1247277

HDA11
Histone deacetylase 11

1

20

High-throughput

0.536

High

1247284

NPAS1
Neuronal PAS domain-containing protein 1

1

6

High-throughput

0.536

High

1247286

RBM4B
RNA-binding protein 4B

1

16

High-throughput

0.536

High

1247287

MBB1A
Myb-binding protein 1A

1

5

High-throughput

0.536

High

1247291

RPF1
Ribosome production factor 1

1

5

High-throughput

0.536

High

1247295

LYAR
Cell growth-regulating nucleolar protein

1

4

High-throughput

0.536

High

1247301

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.536

High

1247266

ARHGJ
Rho guanine nucleotide exchange factor 19

2

12

High-throughput

0.521

High

1247294

ARHG4
Rho guanine nucleotide exchange factor 4

2

5

High-throughput

0.521

High

1247296

RHG23
Rho GTPase-activating protein 23

2

4

High-throughput

0.521

High

628364

CD33
Myeloid cell surface antigen CD33

1

2

High-throughput

0.514

High

1247273

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.514

High

261511

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

1117189

THOC5
THO complex subunit 5

1

0

High-throughput

0.513

High

1247272

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

1247278

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

352711

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

4

High-throughput

0.508

High

1006079

DLG4
Disks large homolog 4

1

3

High-throughput

0.494

High

295595

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.489

High

859876

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.489

High

1247269

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1247282

VPS35
Vacuolar protein sorting-associated protein 35

1

1

High-throughput

0.489

High

172969

XPO1
Exportin-1

1

16

High-throughput

0.479

High

274634

DNJB6
DnaJ homolog subfamily B member 6

1

14

High-throughput

0.479

High

341600

EYA4
Protein phosphatase EYA4

1

17

High-throughput

0.479

High

401015

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

406301

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

810172

RL3
Large ribosomal subunit protein uL3

1

8

High-throughput

0.479

High

830943

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

879204

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

16

High-throughput

0.479

High

1004727

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1023250

RBM3
RNA-binding protein 3

1

17

Small-scale

0.479

High

1040834

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

1140443

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.479

High

1161501

IF16
Gamma-interferon-inducible protein 16

1

6

High-throughput

0.479

High

1247271

DNJC9
DnaJ homolog subfamily C member 9

1

17

High-throughput

0.479

High

1247274

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1247299

XPO7
Exportin-7

1

15

High-throughput

0.479

High

1247303

3BP1
SH3 domain-binding protein 1

1

5

High-throughput

0.479

High

1247270

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1247276

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

760834

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

High-throughput

0.445

High

904850

MECP2
Methyl-CpG-binding protein 2

1

9

High-throughput

0.445

High

1006485

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.445

High

1127569

FAT1
Protocadherin Fat 1

1

3

High-throughput

0.445

High

1130309

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

10

High-throughput

0.445

High

106128

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

345965

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.437

High

1247289

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

1247300

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

High-throughput

0.437

High

278877

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.426

High

886972

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.408

High

61533

VWA8
von Willebrand factor A domain-containing protein 8

1

11

High-throughput

0.407

High

1247283

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

18

High-throughput

0.407

High

1247292

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

20

High-throughput

0.407

High

1127411

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1247280

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1247268

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025