HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	30604749, 31127101, 30804502, 36598580
Identification Methods	pull down, x-ray crystallography, unspecified method, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 4911
+	Hs
		917128 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		ANK2_HUMAN (2103-4261): 3.06e-90: 334: 11.09
+	Hs
		917338 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		331767 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Sc
		356466 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET1_YEAST (4555-4911): 4.81e-78: 286: 25.80
+	Hs
		917879 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD3_HUMAN (1-668): 2.87e-64: 246: 13.52
+	Hs
		165658 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Sc
		356561 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET2_YEAST (4760-4910): 9.54e-57: 215: 27.63
+	Hs
		917277 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		917145 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		917182 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		917762 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD1_HUMAN (1010-1602): 1.56e-13: 80.4: 11.26
+	Hs
		917683 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		918135 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152623 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82