HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: HDAC8 (Q9BY41)
Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-)
Gene: HDAC8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	10926844, 21499270
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 377
+	Mm
		140249 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC1_MOUSE (6-376): 0: 540: 39.79
+	Hs
		917226 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC1_HUMAN (6-376): 0: 539: 39.79
+	Dm
		950398 H4_DROME (1-103): 4.51e-48: 150: 99.03		HDAC1_DROME (10-376): 0: 529: 40.22
+	Hs
		917682 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC2_HUMAN (11-376): 3.92e-180: 511: 40.60
+	Mm
		918237 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC2_MOUSE (11-376): 1.87e-179: 509: 40.60
+	At
		886854 H4_ARATH (1-103): 3.47e-48: 150: 98.06		HDA6_ARATH (1-377): 9.96e-175: 496: 40.53
+	Hs
		177252 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC3_HUMAN (12-376): 1.22e-173: 492: 40.60
+	Sc
		356336 H4_YEAST (18-103): 6.13e-41: 132: 90.70		RPD3_YEAST (7-375): 1.14e-179: 507: 40.27
+	Sp
		140573 H4_SCHPO (18-103): 4.87e-42: 135: 89.54		PHD1_SCHPO (11-376): 6.03e-165: 470: 34.96
+	Sc
		356604 H4_YEAST (18-103): 6.13e-41: 132: 90.70		HOS2_YEAST (13-376): 1.35e-157: 452: 36.41
+	Hs
		880666 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC4_HUMAN (1-366): 8.21e-128: 394: 20.76
+	Sc
		356643 H4_YEAST (18-103): 6.13e-41: 132: 90.70		HDA1_YEAST (6-333): 5.27e-130: 390: 23.66
+	Hs
		918077 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC6_HUMAN (1-328): 2.59e-94: 307: 24.78