HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25281560, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 793
+	Hs
		1087358 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		UHRF1_HUMAN (1-793): 0: 893: 100.00
+	Hs
		707721 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		UHRF1_HUMAN (1-793): 0: 893: 100.00
+	Mm
		500579 H2B1F_MOUSE (1-126): 7.96e-53: 164: 99.21		UHRF1_MOUSE (1-793): 0: 821: 73.32
+	Hs
		241591 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61
+	Hs
		918541 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61
+	Hs
		1018625 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		241517 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		918325 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		707612 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		1059648 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		1059777 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		241527 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		918368 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		707635 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		886109 H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		1059827 H2B1L_HUMAN (1-126): 2.18e-52: 163: 98.41		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		918760 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		BAZ2A_HUMAN (138-417): 1.39e-38: 157: 17.87
+	Hs
		1087459 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		KDM5B_HUMAN (227-383): 6.15e-32: 136: 20.35
+	Dm
		355270 H2B_DROME (36-126): 9.18e-47: 148: 94.51		Q9V9T4_DROME (131-366): 5.64e-35: 145: 20.58
+	Hs
		152598 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		KMT2D_HUMAN (313-363): 2.86e-11: 69.9: 48.08