HitPredict

Interactor 1: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Interactor 2: GNDS (Q12967)
Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)
Gene: RALGDS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	10922060, 11786539, 10085114, 23236378
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 914
+	Hs
		897883 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Dm
		442968 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9GR11_DROME (65-887): 7.88e-171: 517: 27.52
+	Dm
		442959 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q86BI2_DROME (65-887): 5.66e-170: 515: 27.40
+	Dm
		442969 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9U4U5_DROME (65-887): 4.47e-166: 511: 27.40
+	Hs
		156397 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RGRF2_HUMAN (34-651): 2.45e-135: 437: 18.07
+	Hs
		313169 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RPGF3_HUMAN (30-680): 3e-125: 403: 15.69
+	Hs
		919656 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF4_HUMAN (30-650): 4.1e-128: 412: 16.26
+	Hs
		313171 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF3_HUMAN (30-680): 3e-125: 403: 15.69
+	Hs
		919657 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF5_HUMAN (53-648): 2.74e-121: 382: 16.18
+	Hs
		919645 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RGDSR_HUMAN (176-650): 3.89e-111: 351: 40.84
+	Ce
		1089983 RAP1_CAEEL (1-184): 6.18e-73: 219: 80.95		Q19770_CAEEL (237-817): 2.5e-92: 307: 12.11
+	Hs
		919653 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF6_HUMAN (322-772): 3.38e-80: 286: 15.86
+	Dm
		442976 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9VMF3_DROME (359-614): 2.99e-64: 238: 22.66
+	Hs
		925267 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RPGF1_HUMAN (370-660): 1.16e-67: 247: 26.71
+	Hs
		919625 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF1_HUMAN (370-660): 1.16e-67: 247: 26.71
+	Hs
		897964 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00
+	Hs
		919681 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00
+	Hs
		925226 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		SOS1_HUMAN (16-336): 1.15e-38: 158: 14.01
+	Hs
		171541 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RGL2_HUMAN (62-253): 1.03e-18: 93.5: 20.20
+	Hs
		171545 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RGL2_HUMAN (62-253): 1.03e-18: 93.5: 20.20