HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: HERC4 (Q5GLZ8)
Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)
Gene: HERC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	29643511, 22496338
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 1057
+	Hs
		919860 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP1_HUMAN (413-1055): 0: 632: 20.87
+	Hs
		125808 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		WWP2_HUMAN (374-1055): 0: 619: 20.66
+	Hs
		125262 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		WWP2_HUMAN (374-1055): 0: 619: 20.66
+	Hs
		125335 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP2_HUMAN (374-1055): 0: 619: 20.66
+	Hs
		1294888 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ITCH_HUMAN (480-1055): 0: 600: 21.48
+	Hs
		919827 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ITCH_HUMAN (480-1055): 0: 600: 21.48
+	Hs
		808052 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		NEDD4_HUMAN (384-1055): 0: 572: 17.84
+	Hs
		808078 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NEDD4_HUMAN (384-1055): 0: 572: 17.84
+	Hs
		919867 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF2_HUMAN (503-1054): 0: 572: 20.98
+	Hs
		919834 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NED4L_HUMAN (435-1055): 0: 567: 20.27
+	Hs
		919762 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HECW1_HUMAN (383-1056): 2.16e-177: 562: 20.79
+	Hs
		919782 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HACE1_HUMAN (342-1051): 2.8e-179: 548: 18.73
+	Hs
		919889 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HECW2_HUMAN (393-1056): 2.05e-170: 543: 19.97
+	Hs
		849311 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		UBE3A_HUMAN (442-1057): 5.58e-173: 531: 29.50
+	Hs
		919710 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBE3A_HUMAN (442-1057): 5.58e-173: 531: 29.50
+	Hs
		919869 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF1_HUMAN (609-1054): 1.18e-172: 526: 22.33
+	Hs
		919733 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HERC1_HUMAN (151-598): 6.53e-62: 234: 21.49
+	Hs
		919895 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HERC5_HUMAN (1-205): 1.36e-48: 190: 28.31
+	Hs
		319766 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		HERC2_HUMAN (4-157): 1.7e-12: 74.3: 30.63
+	Hs
		319786 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HERC2_HUMAN (4-157): 1.7e-12: 74.3: 30.63