Protein: CWC22
Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)

Gene: CWC22
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q9HCG8

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

807590

IF4A3
Eukaryotic initiation factor 4A-III

9

20

Small-scale

0.974

High

158593

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

2

High-throughput

0.667

High

733514

GP183
G-protein coupled receptor 183

3

3

High-throughput

0.667

High

1439048

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

1

High-throughput

0.667

High

872029

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

1

High-throughput

0.662

High

1439041

E41L5
Band 4.1-like protein 5

3

7

High-throughput

0.662

High

1353333

DOK4
Docking protein 4

3

0

High-throughput

0.638

High

1434870

DEN2D
DENN domain-containing protein 2D

3

0

High-throughput

0.638

High

1335386

CAMKV
CaM kinase-like vesicle-associated protein

4

4

High-throughput

0.636

High

1369307

EDA
Ectodysplasin-A

4

1

High-throughput

0.630

High

139612

PESC
Pescadillo homolog

2

1

High-throughput

0.628

High

217527

E41L2
Band 4.1-like protein 2

2

7

High-throughput

0.628

High

1399824

ERMAP
Erythroid membrane-associated protein

2

2

High-throughput

0.628

High

1439054

E41L3
Band 4.1-like protein 3

2

7

High-throughput

0.628

High

1132988

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.618

High

1198210

PDCD4
Programmed cell death protein 4

1

5

High-throughput

0.618

High

1414577

DDX23
Probable ATP-dependent RNA helicase DDX23

1

10

High-throughput

0.618

High

1439052

PRP19
Pre-mRNA-processing factor 19

2

9

Small-scale

0.611

High

845481

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

2

High-throughput

0.609

High

639169

SYT1
Synaptotagmin-1

3

1

High-throughput

0.604

High

966897

1433G
14-3-3 protein gamma

2

12

High-throughput

0.601

High

1049807

1433F
14-3-3 protein eta

2

11

High-throughput

0.601

High

1433636

E41L1
Band 4.1-like protein 1

2

7

High-throughput

0.601

High

329108

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.580

High

1439051

DDX41
Probable ATP-dependent RNA helicase DDX41

1

7

High-throughput

0.575

High

1330744

SIGL1
SIGLEC family-like protein 1

2

1

High-throughput

0.574

High

1163763

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

7

High-throughput

0.553

High

1125833

FRG1
Protein FRG1

1

0

High-throughput

0.549

High

1439056

FA32A
Protein FAM32A

1

0

High-throughput

0.549

High

1331860

SYT2
Synaptotagmin-2

2

1

High-throughput

0.549

High

564397

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

445265

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

462651

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

11

High-throughput

0.536

High

471262

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.536

High

478214

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

854318

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

941571

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.536

High

1160094

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.536

High

1160307

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

15

High-throughput

0.536

High

1228212

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

4

High-throughput

0.536

High

1432473

E41LB
Band 4.1-like protein 4B

1

6

High-throughput

0.536

High

1439047

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

1384028

EXOS8
Exosome complex component RRP43

1

2

High-throughput

0.508

High

1127502

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

1249851

BTNL9
Butyrophilin-like protein 9

1

2

High-throughput

0.489

High

1325087

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.489

High

134872

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.479

High

223347

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

242995

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

248099

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

285483

EED
Polycomb protein EED

1

16

High-throughput

0.479

High

373202

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.479

High

406670

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

601867

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

Small-scale

0.479

High

696566

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

730263

1433B
14-3-3 protein beta/alpha

1

11

High-throughput

0.479

High

762051

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

769234

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

770305

RL22
Large ribosomal subunit protein eL22

1

4

High-throughput

0.479

High

879489

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

905165

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

971110

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

1045793

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1101038

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

High-throughput

0.479

High

1107233

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1127176

RBM39
RNA-binding protein 39

1

17

High-throughput

0.479

High

1140892

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1227497

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

1258390

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

1290743

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.479

High

1313444

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1338978

NUP43
Nucleoporin Nup43

1

16

High-throughput

0.479

High

1346938

SNIP1
Smad nuclear-interacting protein 1

1

2

High-throughput

0.479

High

1367329

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1371708

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.479

High

1387574

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.479

High

1396820

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

1404421

CDC5L
Cell division cycle 5-like protein

1

8

High-throughput

0.479

High

1436427

BRD9
Bromodomain-containing protein 9

1

7

High-throughput

0.479

High

1439042

ANLN
Anillin

1

5

High-throughput

0.479

High

1439043

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1439045

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1439049

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1439053

FBW1A
F-box/WD repeat-containing protein 1A

1

7

High-throughput

0.479

High

1105719

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.460

High

335916

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

1201284

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.458

High

1439058

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.458

High

767341

MERL
Merlin

1

7

High-throughput

0.445

High

1054147

BTK
Tyrosine-protein kinase BTK

1

1

High-throughput

0.445

High

1439055

LC7L2
Putative RNA-binding protein Luc7-like 2

1

4

High-throughput

0.445

High

412642

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

1255629

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1393716

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1433945

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

216024

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.426

High

1335890

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.426

High

1413989

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.426

High

1439044

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.426

High

516129

CT456
Cancer/testis antigen family 45 member A6

1

2

High-throughput

0.407

High

914481

EFNB2
Ephrin-B2

1

1

High-throughput

0.407

High

1317048

FAM9A
Protein FAM9A

3

0

High-throughput

0.347

High

1322279

FMR1N
FMR1 neighbor protein

3

0

High-throughput

0.347

High

935455

FGF8
Fibroblast growth factor 8

3

0

High-throughput

0.345

High

640621

MK
Midkine

2

0

High-throughput

0.328

High

1256738

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

762417

BTC
Probetacellulin [Cleaved into: Betacellulin

1

0

High-throughput

0.279

Low

1311033

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

1404221

SEC62
Translocation protein SEC62

1

0

High-throughput

0.279

Low

1428717

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.279

Low

1439046

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.279

Low

1439050

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.249

Low

1288455

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.232

Low

1331429

MB213
Protein mab-21-like 3

1

0

High-throughput

0.232

Low

1429598

NUAK2
NUAK family SNF1-like kinase 2

1

0

High-throughput

0.232

Low

1439057

INSL6
Insulin-like peptide INSL6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025