HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: RNFT1 (Q5M7Z0)
E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1)
Gene: RNFT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19690564
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 435
+	Hs
		919766 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SYVN1_HUMAN (137-419): 2.63e-64: 219: 13.84
+	Hs
		1356614 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		AMFR_HUMAN (137-416): 2.16e-48: 176: 15.33
+	Hs
		849484 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		AMFR_HUMAN (137-416): 2.16e-48: 176: 15.33
+	Hs
		919902 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		AMFR_HUMAN (137-416): 2.16e-48: 176: 15.33
+	Hs
		610305 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		CBL_HUMAN (147-433): 7.09e-43: 163: 13.64
+	Hs
		610333 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		CBL_HUMAN (147-433): 7.09e-43: 163: 13.64
+	Mm
		895981 UB2D1_MOUSE (1-147): 7.06e-83: 241: 89.12		CBLB_MOUSE (138-426): 9.14e-39: 151: 12.13
+	Hs
		919717 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		CBLB_HUMAN (138-426): 1.22e-38: 150: 12.13
+	Hs
		1204871 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		GOLI_HUMAN (272-425): 1.03e-27: 115: 15.15
+	Hs
		849359 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		GOLI_HUMAN (272-425): 1.03e-27: 115: 15.15
+	Hs
		919772 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		GOLI_HUMAN (272-425): 1.03e-27: 115: 15.15
+	Hs
		1356934 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN150_HUMAN (304-427): 2.31e-25: 109: 14.50
+	Hs
		849485 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		RN150_HUMAN (304-427): 2.31e-25: 109: 14.50
+	Hs
		919789 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN149_HUMAN (309-428): 1.95e-25: 109: 15.87
+	Hs
		919903 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN150_HUMAN (304-427): 2.31e-25: 109: 14.50
+	Hs
		849382 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		RN128_HUMAN (302-430): 6.02e-22: 99.2: 19.42
+	Zm
		74334 B4FC97_MAIZE (1-147): 3e-83: 242: 79.59		B6U926_MAIZE (331-429): 1.28e-21: 97.6: 18.27
+	Zm
		79637 B6SZE0_MAIZE (1-147): 3.82e-83: 242: 79.59		B6U926_MAIZE (331-429): 1.28e-21: 97.6: 18.27
+	Hs
		919736 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN151_HUMAN (367-424): 3.74e-18: 85.2: 37.10
+	Mm
		895982 UB2D1_MOUSE (1-147): 7.06e-83: 241: 89.12		RNF41_MOUSE (369-417): 9.92e-14: 73.7: 40.00