Protein: IMA3
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)

Gene: IMA3, KPNA4
Organism: Homo sapiens
Interactions: 195
UniProt ID: O00629

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

134978

NUP50
Nuclear pore complex protein Nup50

7

20

High-throughput

0.971

High

134900

IMB1
Importin subunit beta-1

5

20

Small-scale

0.931

High

134832

RCC1
Regulator of chromosome condensation

5

2

Small-scale

0.929

High

134867

RAN
GTP-binding nuclear protein Ran

3

5

High-throughput

0.871

High

131338

IMA4
Importin subunit alpha-4

2

7

High-throughput

0.789

High

134821

ESR1
Estrogen receptor

2

9

High-throughput

0.737

High

134828

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

5

6

High-throughput

0.721

High

134855

MECP2
Methyl-CpG-binding protein 2

4

7

High-throughput

0.704

High

134898

KIF22
Kinesin-like protein KIF22

4

3

High-throughput

0.704

High

134868

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.698

High

134890

MTA1
Metastasis-associated protein MTA1

4

9

High-throughput

0.692

High

134850

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.691

High

134943

TNPO1
Transportin-1

1

20

High-throughput

0.691

High

134945

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

5

High-throughput

0.691

High

134910

NCBP3
Nuclear cap-binding protein subunit 3

4

2

High-throughput

0.676

High

134892

HDAC1
Histone deacetylase 1

3

12

High-throughput

0.675

High

134958

IER2
Immediate early response gene 2 protein

3

1

High-throughput

0.667

High

134819

MYC
Myc proto-oncogene protein

3

7

Small-scale

0.664

High

134884

NCBP1
Nuclear cap-binding protein subunit 1

3

5

High-throughput

0.662

High

134881

CTSL2
CTD small phosphatase-like protein 2

3

4

Small-scale

0.651

High

134861

XPO2
Exportin-2

1

14

Small-scale

0.647

High

134853

NU153
Nuclear pore complex protein Nup153

2

20

High-throughput

0.628

High

134858

NCBP2
Nuclear cap-binding protein subunit 2

2

5

High-throughput

0.628

High

134866

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

4

High-throughput

0.628

High

134878

HSF1
Heat shock factor protein 1

2

4

High-throughput

0.628

High

134948

P121A
Nuclear envelope pore membrane protein POM 121

2

16

High-throughput

0.628

High

134970

DDX21
Nucleolar RNA helicase 2

2

4

High-throughput

0.628

High

134971

MRGBP
MRG/MORF4L-binding protein

2

2

High-throughput

0.628

High

134823

P53
Cellular tumor antigen p53

2

1

Small-scale

0.624

High

134880

TF65
Transcription factor p65

3

9

Small-scale

0.624

High

134987

NCOR2
Nuclear receptor corepressor 2

2

5

Small-scale

0.619

High

134924

ARMC8
Armadillo repeat-containing protein 8

1

9

High-throughput

0.618

High

134956

CIC
Protein capicua homolog

1

7

High-throughput

0.618

High

134893

CUL3
Cullin-3

2

13

High-throughput

0.611

High

134918

BCOR
BCL-6 corepressor

2

9

Small-scale

0.611

High

134944

KAT5
Histone acetyltransferase KAT5

2

7

High-throughput

0.606

High

134984

FA50B
Protein FAM50B

2

1

High-throughput

0.606

High

134845

CBX5
Chromobox protein homolog 5

2

16

Small-scale

0.601

High

134906

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

Small-scale

0.598

High

134820

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

12

High-throughput

0.586

High

134807

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

134909

LARP7
La-related protein 7

2

7

High-throughput

0.584

High

134817

MED26
Mediator of RNA polymerase II transcription subunit 26

2

0

High-throughput

0.576

High

134973

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

2

High-throughput

0.573

High

134985

PLAP
Phospholipase A-2-activating protein

1

6

High-throughput

0.573

High

134873

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.569

High

134891

SQSTM
Sequestosome-1

2

3

High-throughput

0.563

High

134808

NUPR1
Nuclear protein 1

1

4

High-throughput

0.561

High

134962

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.553

High

134848

RECQ1
ATP-dependent DNA helicase Q1

1

6

Small-scale

0.552

High

134833

WT1
Wilms tumor protein

1

9

High-throughput

0.541

High

134851

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

134896

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.541

High

134897

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.541

High

133234

NOP56
Nucleolar protein 56

1

13

High-throughput

0.536

High

134801

CUX2
Homeobox protein cut-like 2

1

2

High-throughput

0.536

High

134804

MCES
mRNA cap guanine-N7 methyltransferase

1

5

High-throughput

0.536

High

134810

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

6

High-throughput

0.536

High

134811

MCE1
mRNA-capping enzyme

1

4

High-throughput

0.536

High

134816

MTA2
Metastasis-associated protein MTA2

1

9

High-throughput

0.536

High

134818

MBD3
Methyl-CpG-binding domain protein 3

1

3

High-throughput

0.536

High

134826

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.536

High

134836

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.536

High

134843

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

134846

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

134847

RAGP1
Ran GTPase-activating protein 1

1

3

High-throughput

0.536

High

134854

RBP2
E3 SUMO-protein ligase RanBP2

1

9

High-throughput

0.536

High

134859

HMGA2
High mobility group protein HMGI-C

1

1

High-throughput

0.536

High

134864

NU107
Nuclear pore complex protein Nup107

1

1

High-throughput

0.536

High

134865

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.536

High

134870

SUMO1
Small ubiquitin-related modifier 1

1

2

High-throughput

0.536

High

134871

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.536

High

134874

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.536

High

134875

GTF2I
General transcription factor II-I

1

4

High-throughput

0.536

High

134879

SET
Protein SET

1

1

High-throughput

0.536

High

134883

RBBP4
Histone-binding protein RBBP4

1

10

High-throughput

0.536

High

134885

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.536

High

134899

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.536

High

134901

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

High-throughput

0.536

High

134904

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

134911

AKIR2
Akirin-2

1

3

High-throughput

0.536

High

134914

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.536

High

134922

RAI1
Retinoic acid-induced protein 1

1

4

High-throughput

0.536

High

134925

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

2

High-throughput

0.536

High

134938

P66B
Transcriptional repressor p66-beta

1

4

High-throughput

0.536

High

134940

HDAC2
Histone deacetylase 2

1

13

High-throughput

0.536

High

134942

SMRC1
SWI/SNF complex subunit SMARCC1

1

5

High-throughput

0.536

High

134950

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.536

High

134953

KI20B
Kinesin-like protein KIF20B

1

7

High-throughput

0.536

High

134965

PHAX
Phosphorylated adapter RNA export protein

1

3

High-throughput

0.536

High

134969

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

20

High-throughput

0.536

High

134813

TRIM3
Tripartite motif-containing protein 3

2

6

Small-scale

0.533

High

134863

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.518

High

134830

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.515

High

134837

ARRB2
Beta-arrestin-2

1

2

High-throughput

0.515

High

134812

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

134857

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

134869

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.513

High

134988

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

134802

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

134814

CDC45
Cell division control protein 45 homolog

1

2

High-throughput

0.501

High

134824

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

134827

NPM
Nucleophosmin

1

4

Small-scale

0.501

High

134849

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.501

High

134882

MEF2C
Myocyte-specific enhancer factor 2C

1

1

High-throughput

0.501

High

134895

CUL4B
Cullin-4B

1

13

Small-scale

0.501

High

134908

HIF1A
Hypoxia-inducible factor 1-alpha

1

13

Small-scale

0.501

High

134937

ZN526
Zinc finger protein 526

1

4

High-throughput

0.501

High

134941

CBP
CREB-binding protein

1

12

High-throughput

0.501

High

134961

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

High-throughput

0.501

High

134964

RANB3
Ran-binding protein 3

1

20

High-throughput

0.501

High

134887

TADBP
TAR DNA-binding protein 43

1

3

Small-scale

0.500

High

134923

F90A1
Protein FAM90A1

1

2

High-throughput

0.489

High

134977

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

4

Small-scale

0.481

High

134917

ABRX1
BRCA1-A complex subunit Abraxas 1

1

0

High-throughput

0.480

High

134982

EXO1
Exonuclease 1

1

0

Small-scale

0.480

High

63862

RGPD3
RanBP2-like and GRIP domain-containing protein 3

1

20

High-throughput

0.479

High

68260

P20L1
PHD finger protein 20-like protein 1

1

2

High-throughput

0.479

High

72691

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

15

High-throughput

0.479

High

134803

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

134806

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

134809

CCNT1
Cyclin-T1

1

2

High-throughput

0.479

High

134815

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

134829

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.479

High

134831

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

134835

PML
Protein PML

1

7

Small-scale

0.479

High

134839

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

134841

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

134842

WASP
Actin nucleation-promoting factor WAS

1

5

Small-scale

0.479

High

134844

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.479

High

134852

CTCF
Transcriptional repressor CTCF

1

7

Small-scale

0.479

High

134862

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

134872

ACTC
Actin, alpha cardiac muscle 1

1

4

High-throughput

0.479

High

134877

H33
Histone H3.3

1

7

Small-scale

0.479

High

134886

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

134889

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.479

High

134894

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

134902

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

134905

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

134915

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

134920

MEPCE
7SK snRNA methylphosphate capping enzyme

1

6

High-throughput

0.479

High

134932

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

134934

COP1
E3 ubiquitin-protein ligase COP1

1

15

High-throughput

0.479

High

134936

PARD3
Partitioning defective 3 homolog

1

1

Small-scale

0.479

High

134939

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

134946

OPTN
Optineurin

1

6

High-throughput

0.479

High

134947

TRI11
E3 ubiquitin-protein ligase TRIM11

1

1

Small-scale

0.479

High

134955

NACC1
Nucleus accumbens-associated protein 1

1

16

Small-scale

0.479

High

134959

AICDA
Single-stranded DNA cytosine deaminase

1

5

Small-scale

0.479

High

134966

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.479

High

134967

SENP2
Sentrin-specific protease 2

1

4

Small-scale

0.479

High

134974

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.479

High

134976

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

134986

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

134834

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.458

High

134951

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

134972

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

134975

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

134903

SF01
Splicing factor 1

1

5

High-throughput

0.457

High

65034

P121C
Nuclear envelope pore membrane protein POM 121C

1

14

High-throughput

0.445

High

134822

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.445

High

134825

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

134838

MERL
Merlin

1

2

High-throughput

0.445

High

134876

CBX1
Chromobox protein homolog 1

1

16

Small-scale

0.445

High

134888

CBX3
Chromobox protein homolog 3

1

16

Small-scale

0.445

High

134913

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

134921

RGPD4
RanBP2-like and GRIP domain-containing protein 4

1

20

High-throughput

0.445

High

134927

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.445

High

134931

ZBT34
Zinc finger and BTB domain-containing protein 34

1

18

Small-scale

0.445

High

134949

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.445

High

134981

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.445

High

134907

NTRK3
NT-3 growth factor receptor

1

4

Small-scale

0.439

High

134919

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

134805

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

134935

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.426

High

134860

NKX25
Homeobox protein Nkx-2.5

1

4

High-throughput

0.408

High

134912

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

1

20

High-throughput

0.408

High

134916

SCND3
SCAN domain-containing protein 3

1

1

High-throughput

0.408

High

134929

RYBP
RING1 and YY1-binding protein

1

1

Small-scale

0.408

High

134952

PKH4B
Pleckstrin homology domain-containing family G member 4B

1

1

High-throughput

0.408

High

134960

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.408

High

134963

ADNP
Activity-dependent neuroprotector homeobox protein

1

3

High-throughput

0.408

High

134968

ZN532
Zinc finger protein 532

1

3

High-throughput

0.408

High

134979

MRTFB
Myocardin-related transcription factor B

1

1

High-throughput

0.408

High

134980

TPX2
Targeting protein for Xklp2

1

3

High-throughput

0.408

High

134983

DMTF1
Cyclin-D-binding Myb-like transcription factor 1

1

2

High-throughput

0.408

High

134840

VGFR2
Vascular endothelial growth factor receptor 2

1

0

High-throughput

0.391

High

134930

HJURP
Holliday junction recognition protein

1

0

High-throughput

0.391

High

134933

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

0

High-throughput

0.391

High

134856

AFF2
AF4/FMR2 family member 2

1

2

High-throughput

0.373

High

134957

SOST
Sclerostin

2

0

High-throughput

0.328

High

64572

MYH7B
Myosin-7B

1

0

High-throughput

0.279

Low

134926

CI040
Uncharacterized protein C9orf40

1

0

High-throughput

0.279

Low

134928

SELH
Selenoprotein H

1

0

High-throughput

0.279

Low

134954

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024