HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: RNF43 (Q68DV7)
E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43)
Gene: RNF43

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	18313049, 19690564
Identification Methods	pull down, two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 783
+	Hs
		1148281 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF43_HUMAN (1-783): 0: 711: 100.00
+	Hs
		849341 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		RNF43_HUMAN (1-783): 0: 711: 100.00
+	Hs
		1356934 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN150_HUMAN (11-389): 2.67e-80: 266: 16.13
+	Hs
		919903 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN150_HUMAN (11-389): 2.67e-80: 266: 16.13
+	Hs
		1204871 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		GOLI_HUMAN (28-381): 3.32e-78: 259: 18.45
+	Hs
		919789 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN149_HUMAN (36-348): 6.63e-79: 261: 17.59
+	Hs
		849359 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		GOLI_HUMAN (28-381): 3.32e-78: 259: 18.45
+	Hs
		919772 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		GOLI_HUMAN (28-381): 3.32e-78: 259: 18.45
+	Hs
		207572 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF13_HUMAN (33-365): 9.38e-66: 225: 16.52
+	Hs
		207545 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		RNF13_HUMAN (33-365): 9.38e-66: 225: 16.52
+	Hs
		207553 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RNF13_HUMAN (33-365): 9.38e-66: 225: 16.52
+	Hs
		1332598 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN167_HUMAN (23-371): 1.13e-61: 213: 21.47
+	Hs
		919862 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN167_HUMAN (23-371): 1.13e-61: 213: 21.47
+	Hs
		1262545 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ZNRF4_HUMAN (24-364): 9.73e-56: 199: 18.33
+	Hs
		919802 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ZNRF4_HUMAN (24-364): 9.73e-56: 199: 18.33
+	Hs
		610305 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		610333 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		919766 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SYVN1_HUMAN (186-595): 1.11e-42: 166: 15.57
+	Hs
		1356614 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		AMFR_HUMAN (185-512): 5.48e-35: 143: 13.87
+	Hs
		919902 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		AMFR_HUMAN (185-512): 5.48e-35: 143: 13.87