HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: MYLIP (Q8WY64)
E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP)
Gene: MYLIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	30079210, 21685362
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 445
+	Hs
		1264347 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00
+	Hs
		849386 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00
+	Hs
		895861 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00
+	Hs
		896505 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00