Protein: SURF4
Surfeit locus protein 4

Gene: SURF4
Organism: Homo sapiens
Interactions: 202
UniProt ID: O15260

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184467

STING
Stimulator of interferon genes protein

2

1

Small-scale

0.634

High

184484

SPP2B
Signal peptide peptidase-like 2B

3

0

High-throughput

0.634

High

184403

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

2

High-throughput

0.628

High

184509

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.618

High

184414

TMEDA
Transmembrane emp24 domain-containing protein 10

2

5

Small-scale

0.612

High

184443

TMED2
Transmembrane emp24 domain-containing protein 2

2

4

Small-scale

0.612

High

184470

S22A9
Organic anion transporter 7

3

1

High-throughput

0.604

High

184507

YIPF3
Protein YIPF3

2

0

High-throughput

0.602

High

184373

PARP1
Poly [ADP-ribose] polymerase 1

2

1

High-throughput

0.584

High

184380

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

184416

CAV2
Caveolin-2

2

1

High-throughput

0.571

High

184438

DOCK1
Dedicator of cytokinesis protein 1

2

1

High-throughput

0.571

High

184473

DOCK3
Dedicator of cytokinesis protein 3

2

1

High-throughput

0.571

High

184350

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.559

High

184353

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

184370

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.559

High

141797

ACKR2
Atypical chemokine receptor 2

1

1

High-throughput

0.536

High

182410

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

184365

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

184368

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.536

High

184374

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

184376

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

184382

ERD21
ER lumen protein-retaining receptor 1

1

2

High-throughput

0.536

High

184383

FPR2
N-formyl peptide receptor 2

1

1

High-throughput

0.536

High

184385

STOM
Stomatin

1

2

High-throughput

0.536

High

184391

NTR1
Neurotensin receptor type 1

1

1

High-throughput

0.536

High

184394

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

2

High-throughput

0.536

High

184398

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

184402

P2RY2
P2Y purinoceptor 2

1

1

High-throughput

0.536

High

184409

AGRE5
Adhesion G protein-coupled receptor E5

1

2

High-throughput

0.536

High

184419

TPTE
Putative tyrosine-protein phosphatase TPTE

1

1

High-throughput

0.536

High

184442

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.536

High

184476

S15A4
Solute carrier family 15 member 4

1

2

Small-scale

0.536

High

184488

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

184515

LPAR2
Lysophosphatidic acid receptor 2

1

1

High-throughput

0.536

High

184517

GPR35
G-protein coupled receptor 35

1

2

High-throughput

0.536

High

184531

GPR52
G-protein coupled receptor 52

1

1

High-throughput

0.536

High

184532

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

4

High-throughput

0.536

High

184406

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.518

High

184352

SNG1
Synaptogyrin-1

1

0

High-throughput

0.513

High

184360

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.513

High

184362

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

184384

CD27
CD27 antigen

1

0

High-throughput

0.513

High

184388

AA2BR
Adenosine receptor A2b

1

0

High-throughput

0.513

High

184389

V2R
Vasopressin V2 receptor

1

0

High-throughput

0.513

High

184392

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

0

High-throughput

0.513

High

184404

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

184418

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.513

High

184461

T184A
Transmembrane protein 184A

1

0

High-throughput

0.513

High

184478

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.513

High

184496

OPALI
Opalin

1

0

High-throughput

0.513

High

184504

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

184512

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

184521

GP173
Probable G-protein coupled receptor 173

1

0

High-throughput

0.513

High

184523

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.513

High

184527

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

184533

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.513

High

178591

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.493

High

184401

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

184435

SERC3
Serine incorporator 3

1

0

High-throughput

0.493

High

184502

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.493

High

184471

S35F2
Solute carrier family 35 member F2

1

3

High-throughput

0.489

High

184347

SURF4
Surfeit locus protein 4

1

1

High-throughput

0.479

High

184351

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

184355

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.479

High

184356

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

184371

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

184381

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

184395

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

184411

LMAN1
Protein ERGIC-53

1

1

Small-scale

0.479

High

184415

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.479

High

184420

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.479

High

184428

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

184431

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

184440

CUL7
Cullin-7

1

1

High-throughput

0.479

High

184453

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

184464

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

184480

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

184485

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

184490

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

184495

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

184501

DERL1
Derlin-1

1

1

Small-scale

0.479

High

184508

DERL2
Derlin-2

1

1

Small-scale

0.479

High

184526

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.479

High

184500

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

122578

UBXN8
UBX domain-containing protein 8

1

0

High-throughput

0.458

High

125083

LEG9
Galectin-9

1

0

High-throughput

0.458

High

139768

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.458

High

156705

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

164182

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

184349

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

184358

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

184361

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

184363

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

184364

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

184366

RASN
GTPase NRas

1

0

High-throughput

0.458

High

184367

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

184369

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

184375

UBL4A
Ubiquitin-like protein 4A

1

0

High-throughput

0.458

High

184386

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

184397

PGH2
Prostaglandin G/H synthase 2

1

0

Small-scale

0.458

High

184405

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

184421

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

184422

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

184430

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

184432

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

184436

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

184437

CUL3
Cullin-3

1

0

High-throughput

0.458

High

184439

MYPC2
Myosin-binding protein C, fast-type

1

0

High-throughput

0.458

High

184441

RHG19
Rho GTPase-activating protein 19

1

0

High-throughput

0.458

High

184450

MIDN
Midnolin

1

0

High-throughput

0.458

High

184454

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

184459

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

184466

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

184469

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

184486

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

184487

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

184489

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

184492

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

184494

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

184497

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

184498

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

184499

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

184503

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.458

High

184506

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

184510

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.458

High

184511

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

184516

LFG4
Protein lifeguard 4

1

0

High-throughput

0.458

High

184518

NEK6
Serine/threonine-protein kinase Nek6

1

0

High-throughput

0.458

High

184522

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

184525

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

184529

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

184348

MOT7
Monocarboxylate transporter 7

1

1

High-throughput

0.445

High

184354

S19A2
Thiamine transporter 1

1

1

High-throughput

0.445

High

184359

S22A5
Organic cation/carnitine transporter 2

1

1

High-throughput

0.445

High

184390

CTR1
High affinity cationic amino acid transporter 1

1

4

High-throughput

0.445

High

184393

SC6A4
Sodium-dependent serotonin transporter

1

4

High-throughput

0.445

High

184407

S6A12
Sodium- and chloride-dependent betaine transporter

1

4

High-throughput

0.445

High

184408

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

4

High-throughput

0.445

High

184417

SC5A3
Sodium/myo-inositol cotransporter

1

1

High-throughput

0.445

High

184447

SC5A9
Sodium/glucose cotransporter 4

1

1

High-throughput

0.445

High

184448

S35G1
Solute carrier family 35 member G1

1

4

High-throughput

0.445

High

184458

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.445

High

184474

AGRG5
Adhesion G-protein coupled receptor G5

1

1

High-throughput

0.445

High

184481

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

184483

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.445

High

184505

S19A3
Thiamine transporter 2

1

1

High-throughput

0.445

High

184519

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

4

High-throughput

0.445

High

184378

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

184423

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

184424

H31
Histone H3.1

1

1

High-throughput

0.437

High

184426

H33
Histone H3.3

1

1

High-throughput

0.437

High

184456

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

184468

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

184472

S15A3
Solute carrier family 15 member 3

1

2

High-throughput

0.437

High

184493

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

184524

DJC17
DnaJ homolog subfamily C member 17

1

1

High-throughput

0.437

High

178103

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.426

High

184372

ISG15
Ubiquitin-like protein ISG15

1

0

Small-scale

0.426

High

184429

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

184446

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

184449

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

184451

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

184455

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

184491

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.426

High

184520

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.426

High

184530

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

184413

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

67069

S38A8
Solute carrier family 38 member 8

1

1

High-throughput

0.407

High

97208

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

104066

F5H1C8
Solute carrier family 15 member 3

1

2

High-throughput

0.407

High

184452

S35F1
Solute carrier family 35 member F1

1

5

High-throughput

0.407

High

49720

TMM72
Transmembrane protein 72

1

0

High-throughput

0.279

Low

184379

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

184399

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

184433

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.279

Low

184465

NOP9
Nucleolar protein 9

1

0

High-throughput

0.279

Low

184475

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

184477

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.279

Low

184479

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.279

Low

184482

THOC2
THO complex subunit 2

1

0

High-throughput

0.279

Low

184528

FA8A1
Protein FAM8A1

1

0

High-throughput

0.279

Low

184357

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

184377

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

184387

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

184396

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

184400

COIL
Coilin

1

0

High-throughput

0.249

Low

184410

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

184412

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.249

Low

184425

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

184427

NDP
Norrin

1

0

Small-scale

0.249

Low

184444

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

184445

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

184460

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

184462

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

184463

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

184513

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

184514

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.249

Low

843

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

184434

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low

184457

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025