HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.985

Property	Details
Experiments	26186194, 28514442, 32296183, 32049508, 33961781, 22325355, 26752685, 30718280, 19615732, 20725033, 23287719, unassigned1304, 19549727, 22124327, unassigned1260
Identification Methods	affinity chromatography technology, two hybrid, pull down, x-ray crystallography, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Peptidase_C65~UQ_con
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 271
+	Hs
		1291615 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		849408 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		895878 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		1291545 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		1282326 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		851868 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		896520 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Mm
		896585 UBE2N_MOUSE (4-147): 7.67e-69: 206: 47.22		OTUB1_MOUSE (1-271): 3.18e-150: 422: 99.63
+	Ce
		715115 UBC2_CAEEL (1-147): 1e-82: 241: 93.88		OTUBL_CAEEL (3-271): 2.76e-122: 352: 34.42
+	Hs
		896513 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		OTUB2_HUMAN (47-270): 1.25e-104: 305: 47.77
+	At
		1228110 UBC36_ARATH (4-146): 2.79e-43: 141: 49.65		OTU1_ARATH (31-270): 5.75e-113: 329: 42.37