HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 1572
+	Hs
		849351 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		HECW1_HUMAN (1-1572): 0: 1101: 54.65
+	Hs
		919762 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HECW1_HUMAN (1-1572): 0: 1101: 54.65
+	Hs
		849353 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		HUWE1_HUMAN (1007-1571): 2.14e-157: 535: 31.55
+	Hs
		919765 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HUWE1_HUMAN (1007-1571): 2.14e-157: 535: 31.55
+	Hs
		919782 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HACE1_HUMAN (1048-1567): 2.84e-162: 517: 30.62
+	Hs
		919869 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF1_HUMAN (177-586): 4.19e-31: 134: 13.74
+	Hs
		125808 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		125262 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		125335 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		849416 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		NED4L_HUMAN (664-1033): 5.09e-15: 82.9: 15.47
+	Hs
		919834 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NED4L_HUMAN (664-1033): 5.09e-15: 82.9: 15.47
+	Hs
		849444 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		919860 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		808052 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		808078 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		849451 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		SMUF2_HUMAN (653-842): 7.63e-13: 75.6: 18.85
+	Hs
		919867 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF2_HUMAN (653-842): 7.63e-13: 75.6: 18.85
+	Hs
		1294888 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37
+	Hs
		849411 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37
+	Hs
		919827 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37