HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	19690564, 19549727, 32296183, 14562029, 15231748, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid array, two hybrid prey pooling approach, enzymatic study, validated two hybrid
Interaction Type	direct interaction, physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 154
+	Hs
		1377465 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		207572 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF13_HUMAN (77-146): 1.55e-26: 104: 33.80
+	Hs
		1377467 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN115_HUMAN (10-154): 2e-26: 102: 19.08
+	Hs
		207545 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		RNF13_HUMAN (77-146): 1.55e-26: 104: 33.80
+	Hs
		207553 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RNF13_HUMAN (77-146): 1.55e-26: 104: 33.80
+	Hs
		1204871 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		GOLI_HUMAN (57-146): 1.98e-25: 101: 24.44
+	Zm
		74334 B4FC97_MAIZE (1-147): 3e-83: 242: 79.59		B6U926_MAIZE (52-153): 2.57e-25: 101: 29.52
+	Zm
		79637 B6SZE0_MAIZE (1-147): 3.82e-83: 242: 79.59		B6U926_MAIZE (52-153): 2.57e-25: 101: 29.52
+	Hs
		919789 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN149_HUMAN (54-147): 1.09e-25: 102: 34.04
+	Hs
		919917 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN115_HUMAN (10-154): 2e-26: 102: 19.08
+	Hs
		849359 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		GOLI_HUMAN (57-146): 1.98e-25: 101: 24.44
+	Hs
		919772 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		GOLI_HUMAN (57-146): 1.98e-25: 101: 24.44
+	Hs
		1356934 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN150_HUMAN (57-146): 3.61e-24: 98.4: 26.67
+	Hs
		849382 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		919766 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SYVN1_HUMAN (72-152): 3.43e-24: 99.2: 28.40
+	Hs
		919903 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN150_HUMAN (57-146): 3.61e-24: 98.4: 26.67
+	Hs
		1346940 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		919877 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		1332598 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN167_HUMAN (77-143): 4.96e-21: 89.1: 36.77
+	Hs
		919862 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN167_HUMAN (77-143): 4.96e-21: 89.1: 36.77