HitPredict

Interactor 1: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Interactor 2: A16L1 (Q676U5)
Autophagy-related protein 16-1 (APG16-like 1)
Gene: ATG16L1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30196744
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005829 - cytosol GO:0051020 - GTPase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 340 Hs			1 607
+	Hs
		921608 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		A16L1_HUMAN (1-607): 3.73e-164: 483: 100.00
+	Hs
		921751 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		NLE1_HUMAN (441-607): 2.75e-43: 163: 20.34
+	Hs
		920927 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBB1_HUMAN (165-516): 5.41e-43: 159: 17.18
+	Dm
		1358845 WDS_DROME (3-215): 1.22e-57: 192: 19.55		WDS_DROME (279-565): 1.49e-87: 278: 18.27
+	Hs
		560870 GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24		GBB1_HUMAN (165-516): 5.41e-43: 159: 17.18
+	Hs
		921054 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBB4_HUMAN (165-516): 4.49e-42: 156: 16.07
+	Sc
		630844 NLE1_YEAST (2-297): 8.98e-80: 253: 18.55		NLE1_YEAST (42-474): 1.95e-50: 184: 12.40
+	Mm
		921801 GBB2_MOUSE (1-340): 1e-105: 314: 90.29		A16L1_MOUSE (436-605): 2.53e-26: 115: 15.25
+	Mm
		921102 GBB1_MOUSE (1-340): 7.02e-105: 312: 100.00		A16L1_MOUSE (436-605): 2.53e-26: 115: 15.25
+	Hs
		792949 WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93		LIS1_HUMAN (99-438): 6.8e-50: 180: 14.98
+	Hs
		903349 WDR5B_HUMAN (71-340): 2.74e-83: 257: 25.18		WDR5_HUMAN (183-393): 4.59e-20: 93.6: 13.45
+	Hs
		903551 WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93		NLE1_HUMAN (441-607): 2.75e-43: 163: 20.34
+	Hs
		154671 GNB5_HUMAN (129-340): 1.35e-45: 161: 21.46		GBB1_HUMAN (165-516): 5.41e-43: 159: 17.18
+	Hs
		903428 SNR40_HUMAN (130-340): 2.9e-59: 196: 24.30		WDR5_HUMAN (183-393): 4.59e-20: 93.6: 13.45
+	Hs
		903077 WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93		WDR5_HUMAN (183-393): 4.59e-20: 93.6: 13.45