Protein: SH3L1
Adapter SH3BGRL (SH3 domain-binding glutamic acid-rich-like protein 1)

Gene: SH3L1, SH3BGRL
Organism: Homo sapiens
Interactions: 122
UniProt ID: O75368

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

277907

ACTB
Actin, cytoplasmic 1

2

4

High-throughput

0.737

High

277911

ARP3
Actin-related protein 3

2

4

High-throughput

0.737

High

277912

ARP2
Actin-related protein 2

2

4

High-throughput

0.737

High

277917

ACTG
Actin, cytoplasmic 2

2

4

High-throughput

0.737

High

277931

ACTBL
Beta-actin-like protein 2

2

4

High-throughput

0.737

High

277871

SVIL
Supervillin

3

2

High-throughput

0.650

High

277958

MYO5C
Unconventional myosin-Vc

3

2

High-throughput

0.650

High

277969

MYO5B
Unconventional myosin-Vb

3

2

High-throughput

0.650

High

277873

EGFR
Epidermal growth factor receptor

3

3

Small-scale

0.644

High

277896

HSP74
Heat shock 70 kDa protein 4

3

3

Small-scale

0.633

High

277868

SH3L1
Adapter SH3BGRL

1

0

High-throughput

0.586

High

123527

MYO1C
Unconventional myosin-Ic

2

5

High-throughput

0.571

High

179100

ARC1B
Actin-related protein 2/3 complex subunit 1B

2

1

High-throughput

0.571

High

192675

ARPC5
Actin-related protein 2/3 complex subunit 5

2

1

High-throughput

0.571

High

227736

MYO1B
Unconventional myosin-Ib

2

5

High-throughput

0.571

High

240031

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

3

High-throughput

0.571

High

256558

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

1

High-throughput

0.571

High

270289

WDR1
WD repeat-containing protein 1

2

1

High-throughput

0.571

High

277870

MYO1D
Unconventional myosin-Id

2

5

High-throughput

0.571

High

277876

GELS
Gelsolin

2

2

High-throughput

0.571

High

277878

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

1

High-throughput

0.571

High

277880

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

3

High-throughput

0.571

High

277882

PLST
Plastin-3

2

2

High-throughput

0.571

High

277883

AK1A1
Aldo-keto reductase family 1 member A1

2

5

High-throughput

0.571

High

277884

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

2

1

High-throughput

0.571

High

277889

VDAC1
Non-selective voltage-gated ion channel VDAC1

2

1

High-throughput

0.571

High

277891

COF1
Cofilin-1

2

3

High-throughput

0.571

High

277895

AL1B1
Aldehyde dehydrogenase X, mitochondrial

2

2

High-throughput

0.571

High

277899

CAZA2
F-actin-capping protein subunit alpha-2

2

1

High-throughput

0.571

High

277900

CAPZB
F-actin-capping protein subunit beta

2

1

High-throughput

0.571

High

277903

CAZA1
F-actin-capping protein subunit alpha-1

2

1

High-throughput

0.571

High

277904

TXTP
Tricarboxylate transport protein, mitochondrial

2

1

High-throughput

0.571

High

277909

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

3

High-throughput

0.571

High

277910

DEST
Destrin

2

3

High-throughput

0.571

High

277919

S25A3
Solute carrier family 25 member 3

2

1

High-throughput

0.571

High

277922

TWF1
Twinfilin-1

2

3

High-throughput

0.571

High

277924

FLII
Protein flightless-1 homolog

2

2

High-throughput

0.571

High

277926

SRC8
Src substrate cortactin

2

1

High-throughput

0.571

High

277927

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

3

High-throughput

0.571

High

277928

TOM34
Mitochondrial import receptor subunit TOM34

2

1

High-throughput

0.571

High

277930

DREB
Drebrin

2

1

High-throughput

0.571

High

277934

TWF2
Twinfilin-2

2

3

High-throughput

0.571

High

277942

HS105
Heat shock protein 105 kDa

2

4

High-throughput

0.571

High

277943

ARC1A
Actin-related protein 2/3 complex subunit 1A

2

1

High-throughput

0.571

High

277945

SH3K1
SH3 domain-containing kinase-binding protein 1

2

1

High-throughput

0.571

High

277949

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

2

1

High-throughput

0.571

High

277951

TBA1C
Tubulin alpha-1C chain

2

1

High-throughput

0.571

High

277952

COR1B
Coronin-1B

2

2

High-throughput

0.571

High

277959

DD19A
ATP-dependent RNA helicase DDX19A

2

2

High-throughput

0.571

High

277967

DDX25
ATP-dependent RNA helicase DDX25

2

2

High-throughput

0.571

High

277971

MYO6
Unconventional myosin-VI

2

3

High-throughput

0.571

High

277972

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.571

High

277975

MTCH2
Mitochondrial carrier homolog 2

2

1

High-throughput

0.571

High

179279

ARPC2
Actin-related protein 2/3 complex subunit 2

2

0

High-throughput

0.547

High

179431

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.547

High

249389

ACSL4
Long-chain-fatty-acid--CoA ligase 4

2

0

High-throughput

0.547

High

277872

BAG2
BAG family molecular chaperone regulator 2

2

0

High-throughput

0.547

High

277875

HSPB1
Heat shock protein beta-1

2

0

High-throughput

0.547

High

277879

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.547

High

277881

ADT3
ADP/ATP translocase 3

2

0

High-throughput

0.547

High

277886

ITA2
Integrin alpha-2

2

0

High-throughput

0.547

High

277888

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.547

High

277894

PYR1
Multifunctional protein CAD

2

0

High-throughput

0.547

High

277902

HNRPM
Heterogeneous nuclear ribonucleoprotein M

2

0

High-throughput

0.547

High

277906

ARPC4
Actin-related protein 2/3 complex subunit 4

2

0

High-throughput

0.547

High

277916

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

0

High-throughput

0.547

High

277918

TBB4B
Tubulin beta-4B chain

2

0

High-throughput

0.547

High

277925

SQSTM
Sequestosome-1

2

0

High-throughput

0.547

High

277941

IPO4
Importin-4

2

0

High-throughput

0.547

High

277953

FACD2
Fanconi anemia group D2 protein

2

0

High-throughput

0.547

High

277964

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

0

High-throughput

0.547

High

277966

LIMA1
LIM domain and actin-binding protein 1

2

0

High-throughput

0.547

High

277968

PSME2
Proteasome activator complex subunit 2

2

0

High-throughput

0.547

High

277973

RUVB1
RuvB-like 1

2

0

High-throughput

0.547

High

277976

NS1BP
Influenza virus NS1A-binding protein

2

0

High-throughput

0.547

High

171135

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

2

High-throughput

0.536

High

277923

MYO1E
Unconventional myosin-Ie

1

5

High-throughput

0.536

High

277935

MPRIP
Myosin phosphatase Rho-interacting protein

1

1

High-throughput

0.536

High

277948

LRCH3
DISP complex protein LRCH3

1

1

High-throughput

0.536

High

277954

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

3

High-throughput

0.536

High

277962

RAI14
Ankycorbin

1

2

High-throughput

0.536

High

277974

MYO5A
Unconventional myosin-Va

1

3

High-throughput

0.536

High

173791

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

2

1

High-throughput

0.521

High

277944

COR2A
Coronin-2A

2

2

High-throughput

0.521

High

277961

TMOD3
Tropomodulin-3

2

1

High-throughput

0.521

High

277970

COR1C
Coronin-1C

2

2

High-throughput

0.521

High

277893

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.513

High

277901

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.513

High

277932

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.513

High

277937

MYH14
Myosin-14

1

0

High-throughput

0.513

High

277938

ZN397
Zinc finger protein 397

1

0

High-throughput

0.513

High

277939

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

277955

ESF1
ESF1 homolog

1

0

High-throughput

0.513

High

277960

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.513

High

277874

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

Small-scale

0.479

High

277892

EF1B
Elongation factor 1-beta

1

1

Small-scale

0.479

High

277897

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.479

High

277936

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

277957

TRPV4
Transient receptor potential cation channel subfamily V member 4

1

1

High-throughput

0.479

High

277965

TES
Testin

1

1

High-throughput

0.479

High

277869

ATG12
Ubiquitin-like protein ATG12

1

0

Small-scale

0.458

High

277877

PROF1
Profilin-1

1

0

Small-scale

0.458

High

277885

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

277887

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.458

High

277890

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

277908

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

277913

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.458

High

277914

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

Small-scale

0.458

High

277915

RS28
Small ribosomal subunit protein eS28

1

0

Small-scale

0.458

High

277921

RL18A
Large ribosomal subunit protein eL20

1

0

Small-scale

0.458

High

277929

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

277898

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

277905

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

2

0

High-throughput

0.298

High

277920

REEP5
Receptor expression-enhancing protein 5

2

0

High-throughput

0.298

High

277940

RDH11
Retinol dehydrogenase 11

2

0

High-throughput

0.298

High

277947

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

0

High-throughput

0.298

High

277956

SFXN1
Sideroflexin-1

2

0

High-throughput

0.298

High

277963

TM14C
Transmembrane protein 14C

2

0

High-throughput

0.298

High

277946

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

277933

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

Small-scale

0.249

Low

277950

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025