HitPredict

Interactor 1: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Interactor 2: GBG12 (Q9UBI6)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene: GNG12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	19168127, 16301321, 35271311, 34349018, 12782285
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007186 - G protein-coupled receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 340 Hs			1 72
+	Hs
		921761 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG12_HUMAN (1-72): 2.14e-28: 98.2: 100.00
+	Hs
		229238 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG7_HUMAN (6-72): 3.3e-27: 95.1: 77.61
+	Hs
		921516 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG3_HUMAN (3-72): 1.94e-26: 93.2: 57.75
+	Hs
		229237 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBG7_HUMAN (6-72): 3.3e-27: 95.1: 77.61
+	Hs
		887097 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG2_HUMAN (5-72): 3.25e-26: 92.8: 62.32
+	Bt
		920925 GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00		GBG2_BOVIN (5-72): 3.25e-26: 92.8: 62.32
+	Mm
		921088 GBB1_MOUSE (1-340): 7.02e-105: 312: 100.00		GBG2_MOUSE (5-72): 3.25e-26: 92.8: 62.32
+	Hs
		837673 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG4_HUMAN (6-72): 2e-24: 88.2: 57.35
+	Hs
		921771 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG8_HUMAN (5-72): 2.87e-24: 87.8: 49.28
+	Hs
		837687 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG10_HUMAN (6-72): 4.05e-24: 87.4: 44.78
+	Hs
		837672 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBG4_HUMAN (6-72): 2e-24: 88.2: 57.35
+	Hs
		837686 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBG10_HUMAN (6-72): 4.05e-24: 87.4: 44.78
+	Hs
		921517 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG5_HUMAN (6-72): 9.85e-23: 83.6: 46.27
+	Hs
		921515 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG1_HUMAN (13-71): 8.37e-19: 73.9: 41.67
+	Hs
		929139 Q6FHM2_HUMAN (1-340): 1e-105: 314: 90.29		GBG1_HUMAN (13-71): 8.37e-19: 73.9: 41.67
+	Hs
		150115 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBGT2_HUMAN (14-71): 9.26e-19: 73.5: 43.10
+	Bt
		362122 GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00		GBG1_BOVIN (13-71): 4.06e-19: 74.7: 41.67
+	Hs
		150114 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBGT2_HUMAN (14-71): 9.26e-19: 73.5: 43.10
+	Ce
		567432 GBB1_CAEEL (1-340): 7.67e-107: 317: 85.88		GBG_CAEEL (14-72): 5.28e-16: 66.6: 38.98
+	Ce
		105444 GBB1_CAEEL (1-340): 7.67e-107: 317: 85.88		G5ECT6_CAEEL (12-72): 4.38e-15: 64.3: 32.79