HitPredict

Interactor 1: RPAB5 (P62875)
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)
Gene: POLR2L

Interactor 2: RPC8 (Q9Y535)
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)
Gene: POLR3H

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	33961781, 24981860, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003899 - DNA-directed 5'-3' RNA polymerase activity GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 67 Hs			1 204
+	Sc
		604673 RPAB5_YEAST (1-67): 1.8e-30: 103: 72.06		RPC8_YEAST (1-202): 1.09e-72: 220: 42.79
+	Hs
		913889 RPAB5_HUMAN (1-67): 3.73e-35: 114: 100.00		RPB7_HUMAN (1-199): 5.25e-63: 194: 17.59
+	Sp
		143452 RPAB5_SCHPO (1-67): 4.78e-33: 109: 71.64		RPB7_SCHPO (2-198): 2.39e-55: 175: 17.59
+	Sc
		604669 RPAB5_YEAST (1-67): 1.8e-30: 103: 72.06		RPB7_YEAST (1-198): 1.19e-54: 173: 18.00