HitPredict

Interactor 1: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Interactor 2: IFIH1 (Q9BYX4)
Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)
Gene: IFIH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28594325
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 165 Hs			1 1025
+	Mm
		570763 PPIA_MOUSE (1-164): 9.88e-90: 260: 96.34		RIGI_MOUSE (12-1017): 6.92e-139: 442: 26.67
+	Hs
		321885 PPIA_HUMAN (1-165): 2.77e-91: 264: 100.00		RIGI_HUMAN (12-1017): 8.62e-133: 426: 27.64
+	Mm
		1163205 RBP2_MOUSE (3-164): 1.51e-73: 241: 67.28		RIGI_MOUSE (12-1017): 6.92e-139: 442: 26.67
+	Sc
		540592 CYPH_YEAST (4-164): 1.45e-86: 252: 65.84		MPH1_YEAST (283-912): 4.45e-76: 272: 16.69
+	Hs
		133966 PPIA_HUMAN (1-165): 2.77e-91: 264: 100.00		DDX3X_HUMAN (148-595): 7.66e-53: 199: 9.92
+	Hs
		134252 PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28		DDX3X_HUMAN (148-595): 7.66e-53: 199: 9.92
+	Hs
		1271695 PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28		DDX17_HUMAN (217-596): 1.62e-48: 187: 10.88
+	Hs
		571634 PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28		DDX5_HUMAN (216-596): 1.93e-49: 187: 11.54