Protein: AHA1
Hsp90 co-chaperone AHA1 (Activator of Hsp90 ATPase protein 1)

Gene: AHA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 139
UniProt ID: Q12449

Gene Ontology (top 5):
GO:0001671 - ATPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

393563

HSP82
ATP-dependent molecular chaperone HSP82

27

11

Small-scale

0.993

High

580288

HSC82
ATP-dependent molecular chaperone HSC82

12

11

Small-scale

0.979

High

923777

HCH1
Hsp90 co-chaperone HCH1

3

1

Small-scale

0.814

High

1084928

AHA1
Hsp90 co-chaperone AHA1

2

1

Small-scale

0.743

High

525632

HSP71
Heat shock protein SSA1

4

5

High-throughput

0.683

High

922697

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

2

1

Small-scale

0.618

High

518431

IF4A
ATP-dependent RNA helicase eIF4A

2

1

High-throughput

0.611

High

803726

RPN1
26S proteasome regulatory subunit RPN1

2

4

High-throughput

0.611

High

546846

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.601

High

727422

HS104
Heat shock protein 104

2

2

High-throughput

0.584

High

850279

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

671268

SIS1
Protein SIS1

2

2

High-throughput

0.571

High

676493

MAS5
Mitochondrial protein import protein MAS5

2

3

High-throughput

0.571

High

836975

MPG1
Mannose-1-phosphate guanyltransferase

2

1

High-throughput

0.571

High

438347

NOT3
General negative regulator of transcription subunit 3

2

0

High-throughput

0.563

High

825496

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

1

High-throughput

0.558

High

528086

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

820188

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

636382

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

1

High-throughput

0.541

High

368361

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.536

High

386925

TBB
Tubulin beta chain

1

1

High-throughput

0.536

High

470165

SPS1
Sporulation-specific protein 1

1

3

High-throughput

0.536

High

486365

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.536

High

598940

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.536

High

617418

GBB
Guanine nucleotide-binding protein subunit beta

1

1

High-throughput

0.536

High

645015

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.536

High

734238

EF2
Elongation factor 2

1

2

High-throughput

0.536

High

744219

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.536

High

750217

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.536

High

755198

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.536

High

801741

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

803184

ECM29
Proteasome component ECM29

1

2

High-throughput

0.536

High

809105

DUN1
DNA damage response protein kinase DUN1

1

2

High-throughput

0.536

High

811077

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.536

High

817992

IMB4
Importin subunit beta-4

1

2

High-throughput

0.536

High

454022

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

459186

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.513

High

471450

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.513

High

684082

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.513

High

726020

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.513

High

798014

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.513

High

822982

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.513

High

1027304

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

1084640

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.513

High

704805

MSP1
Outer mitochondrial transmembrane helix translocase

1

3

Small-scale

0.512

High

585664

STI1
Heat shock protein STI1

1

4

Small-scale

0.501

High

575543

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.489

High

829815

MAD2
Mitotic spindle checkpoint component MAD2

1

0

High-throughput

0.486

High

826119

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.481

High

1038126

ULP1
Ubiquitin-like-specific protease 1

1

2

High-throughput

0.481

High

383959

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

417199

VDAC1
Non-selective voltage-gated ion channel 1

1

1

Small-scale

0.479

High

435450

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

436240

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

442182

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

455328

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

503310

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

504483

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

512724

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

514899

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

554747

YPK1
Serine/threonine-protein kinase YPK1

1

3

High-throughput

0.479

High

616468

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.479

High

647253

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

661833

TOM40
Mitochondrial import receptor subunit TOM40

1

1

Small-scale

0.479

High

674903

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

689732

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

708602

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

747650

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

750807

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

753661

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

792320

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

802456

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

824818

MLP2
Protein MLP2

1

1

High-throughput

0.479

High

874602

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

1033641

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

1051195

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

1059481

SUB2
ATP-dependent RNA helicase SUB2

1

2

High-throughput

0.479

High

1064836

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

1084578

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

150022

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

410406

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

433912

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

513291

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

585742

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.458

High

636959

CCA1
CCA tRNA nucleotidyltransferase, mitochondrial

1

0

High-throughput

0.458

High

638748

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

High-throughput

0.458

High

680184

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

701753

URA7
CTP synthase 1

1

0

High-throughput

0.458

High

764043

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

764177

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

778600

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

779524

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

806843

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

864864

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

926296

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.458

High

1044174

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

1044519

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

1064517

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

1065621

YP225
Protein PBDC1 homolog

1

0

High-throughput

0.458

High

1084284

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1084426

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

452064

TOM70
Mitochondrial import receptor subunit TOM70

1

5

Small-scale

0.457

High

365240

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.445

High

395030

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

453856

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

481821

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

592596

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.445

High

742737

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

751024

PRS7
26S proteasome regulatory subunit 7 homolog

1

5

High-throughput

0.445

High

811512

XDJ1
DnaJ protein homolog XDJ1

1

3

High-throughput

0.445

High

865118

TCPQ
T-complex protein 1 subunit theta

1

4

High-throughput

0.445

High

865978

DPH4
Diphthamide biosynthesis protein 4

1

2

High-throughput

0.445

High

925159

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.445

High

1039078

IMA1
Importin subunit alpha

1

1

High-throughput

0.445

High

919587

YG5B
Uncharacterized RNA-binding protein YGR250C

1

0

High-throughput

0.438

High

597585

EF3A
Elongation factor 3A

1

4

High-throughput

0.437

High

682431

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

684890

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

712946

PAP
Poly(A) polymerase

1

0

High-throughput

0.426

High

782232

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.426

High

812271

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

837295

REF2
RNA end formation protein 2

1

0

High-throughput

0.426

High

871587

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

1084929

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.426

High

798175

ARPC1
Actin-related protein 2/3 complex subunit 1

1

3

High-throughput

0.417

High

780519

MCR1
NADH-cytochrome b5 reductase 2

1

0

Small-scale

0.292

High

675359

RAD51
DNA repair protein RAD51

1

0

Small-scale

0.288

High

605939

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.279

Low

763204

TOM20
Mitochondrial import receptor subunit TOM20

1

0

Small-scale

0.261

Low

94595

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.251

Low

368203

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.249

Low

677629

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

746978

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

Small-scale

0.249

Low

798114

OM14
Mitochondrial outer membrane protein OM14

1

0

Small-scale

0.249

Low

844669

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

925405

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

Small-scale

0.249

Low

1046098

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

1057300

NVJ2
Nucleus-vacuole junction protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025