HitPredict

Interactor 1: FKB1A (P62942)
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
Gene: FKBP1A

Interactor 2: TRPC6 (Q9Y210)
Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)
Gene: TRPC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15199065
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane GO:0070588 - calcium ion transmembrane transport
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 108 Hs			1 931
+	Rn
		1144001 FKB1A_RAT (1-108): 5.55e-54: 165: 97.22		Q99N78_RAT (1-931): 0: 679: 93.88
+	Hs
		923823 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		TRPC3_HUMAN (49-922): 0: 581: 71.80
+	Hs
		923841 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		TRPC7_HUMAN (57-930): 0: 571: 73.34
+	Rn
		94072 FKB1A_RAT (1-108): 5.55e-54: 165: 97.22		F1LQF7_RAT (66-930): 0: 572: 73.99
+	Rn
		1257461 FKBP4_RAT (2-108): 3.17e-15: 71.3: 27.93		Q8VD38_RAT (93-930): 1.52e-147: 463: 34.77
+	Hs
		972610 FKBP4_HUMAN (2-108): 1.57e-15: 72.4: 27.03		TRPC5_HUMAN (93-930): 1.58e-146: 460: 35.04
+	Hs
		972602 FKBP4_HUMAN (2-108): 1.57e-15: 72.4: 27.03		TRPC4_HUMAN (99-929): 5.49e-143: 451: 36.17
+	Dm
		823165 FKB59_DROME (3-106): 4.05e-15: 71.3: 28.70		TRPL_DROME (105-914): 2.26e-134: 432: 31.13
+	Hs
		823170 FKBP4_HUMAN (2-108): 1.57e-15: 72.4: 27.03		TRPC1_HUMAN (85-910): 2.3e-120: 387: 33.02
+	Rn
		1351538 FKBP4_RAT (2-108): 3.17e-15: 71.3: 27.93		TRPC1_RAT (85-910): 9.2e-110: 357: 30.73
+	Hs
		923838 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		Q9H4D1_HUMAN (64-198): 6e-17: 88: 24.46
+	Hs
		883470 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		RIPK4_HUMAN (64-198): 9.28e-17: 87.2: 24.46
+	Hs
		961567 FKBP3_HUMAN (5-108): 5.68e-42: 138: 40.18		Q9H4D1_HUMAN (64-198): 6e-17: 88: 24.46
+	Hs
		883486 FKBP3_HUMAN (5-108): 5.68e-42: 138: 40.18		RIPK4_HUMAN (64-198): 9.28e-17: 87.2: 24.46
+	Hs
		972586 FKBP4_HUMAN (2-108): 1.57e-15: 72.4: 27.03		Q9H4D1_HUMAN (64-198): 6e-17: 88: 24.46
+	Hs
		883489 FKBP4_HUMAN (2-108): 1.57e-15: 72.4: 27.03		RIPK4_HUMAN (64-198): 9.28e-17: 87.2: 24.46
+	Hs
		1034995 FKBP5_HUMAN (2-108): 3.73e-15: 71.3: 28.44		Q9H4D1_HUMAN (64-198): 6e-17: 88: 24.46
+	Hs
		883504 FKBP5_HUMAN (2-108): 3.73e-15: 71.3: 28.44		RIPK4_HUMAN (64-198): 9.28e-17: 87.2: 24.46