HitPredict

Interactor 1: RL40 (P62987)
Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]
Gene: UBA52

Interactor 2: UBE2O (Q9C0C9)
(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)
Gene: UBE2O

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	33961781, 35271311, 36273042, 19549727
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 1292
+	Hs
		924152 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		UBE2O_HUMAN (40-1292): 0: 1481: 100.00
+	Dm
		1376599 Q9W418_DROME (1-77): 1.45e-41: 145: 98.70		Q9Y165_DROME (701-1106): 6.38e-104: 340: 18.99
+	At
		886690 R27AB_ARATH (1-77): 3.79e-37: 125: 94.81		UBC26_ARATH (822-1243): 5.44e-88: 298: 26.28
+	At
		886693 R27AC_ARATH (1-77): 2.25e-37: 125: 94.81		UBC26_ARATH (822-1243): 5.44e-88: 298: 26.28
+	Hs
		895774 RL40_HUMAN (1-128): 1.05e-56: 174: 100.00		UB2D3_HUMAN (953-1106): 2.98e-61: 207: 22.93
+	Xl
		919927 Q7SY79_XENLA (1-77): 3.33e-41: 145: 98.70		UB2D2_XENLA (953-1106): 1.71e-62: 211: 22.29
+	Dm
		639414 Q9W418_DROME (1-77): 1.45e-41: 145: 98.70		UBCD1_DROME (953-1106): 7.82e-62: 209: 21.66
+	Hs
		896411 RL40_HUMAN (1-128): 1.05e-56: 174: 100.00		UBE2N_HUMAN (956-1103): 1.44e-45: 163: 22.52
+	Hs
		895773 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		UB2D3_HUMAN (953-1106): 2.98e-61: 207: 22.93
+	Hs
		474984 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		UB2D2_HUMAN (953-1106): 1.71e-62: 211: 22.29
+	Hs
		475249 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		UB2D4_HUMAN (953-1106): 2.59e-62: 210: 21.02
+	At
		715116 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		UBC8_ARATH (953-1106): 2.17e-60: 205: 22.29
+	At
		715147 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		UBC10_ARATH (953-1117): 1.29e-59: 203: 23.03
+	At
		715132 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		UBC9_ARATH (953-1117): 2.07e-59: 202: 22.42
+	Hs
		924175 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		UBE2T_HUMAN (956-1135): 5.53e-55: 191: 26.52
+	At
		715157 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		UBC11_ARATH (953-1106): 3.78e-59: 201: 22.29
+	At
		639385 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		UBC1_ARATH (950-1113): 2.87e-56: 193: 24.39
+	Hs
		475044 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		UBE2S_HUMAN (942-1108): 1.64e-49: 177: 27.55
+	Hs
		896410 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		UBE2N_HUMAN (956-1103): 1.44e-45: 163: 22.52
+	Hs
		474958 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		UBE2A_HUMAN (956-1112): 5.42e-42: 152: 26.75