HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: KRT83 (P78385)
Keratin, type II cuticular Hb3 (Hair keratin K2.10) (Keratin-83) (K83) (Type II hair keratin Hb3) (Type-II keratin Kb23)
Gene: KRT83

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 493
+	Hs
		444533 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C7_HUMAN (27-433): 1.98e-161: 467: 53.30
+	Hs
		380590 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C1_HUMAN (80-436): 1.01e-124: 379: 54.60
+	Hs
		924576 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT81_HUMAN (7-482): 4.9e-116: 352: 96.01
+	Hs
		409046 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C8_HUMAN (83-438): 8.25e-114: 346: 58.15
+	Hs
		213936 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT86_HUMAN (1-486): 1e-111: 341: 90.14
+	Hs
		924470 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT85_HUMAN (1-479): 1.25e-102: 318: 80.69
+	Hs
		924679 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C73_HUMAN (2-487): 2.4e-96: 303: 44.27
+	Hs
		924895 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT82_HUMAN (1-490): 8.04e-89: 282: 54.80
+	Hs
		531551 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C5_HUMAN (76-425): 1.12e-73: 245: 58.81
+	Hs
		359480 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C6A_HUMAN (76-425): 1.19e-72: 242: 57.96
+	Hs
		924575 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1H2_HUMAN (8-422): 1.12e-67: 225: 23.87
+	Mm
		1060206 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q148Q7_MOUSE (29-425): 5.03e-66: 223: 55.42
+	Mm
		1141145 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q8BIS2_MOUSE (29-425): 4.08e-66: 223: 55.42
+	Hs
		924741 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT35_HUMAN (8-486): 2.54e-65: 219: 23.75
+	Mm
		403456 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		K2C5_MOUSE (13-425): 8.53e-73: 242: 53.25
+	Hs
		442865 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		KRT35_HUMAN (8-486): 2.54e-65: 219: 23.75