HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 9890893, 10913131, 31980649, 11314042, 8596638, 9804835, 28514442, 20473329, 11960376, 33961781, 20936779, 19380743, 9242692, 21706016, 11027663, 20005866, 19523899, unassigned2173, 22536782
Identification Methods pull down, far western blotting, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, isothermal titration calorimetry, peptide array, anti bait coimmunoprecipitation, tandem affinity purification, two hybrid pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~SH3_1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005911 - cell-cell junction
GO:0007165 - signal transduction
GO:0007173 - epidermal growth factor receptor signaling pathway
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 217
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024