HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32814053, 38182563
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005768 - endosome GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 450
+	Hs
		433352 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		BECN1_HUMAN (1-450): 0: 645: 100.00
+	Hs
		1054133 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		BECN1_HUMAN (1-450): 0: 645: 100.00
+	Hs
		89942 D6PAV9_HUMAN (136-215): 1.71e-11: 65: 20.00		BECN1_HUMAN (1-450): 0: 645: 100.00
+	Hs
		522985 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		BECN1_HUMAN (1-450): 0: 645: 100.00