HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.884

Property	Details
Experiments	25140053, 16729043, 22973453, 24658140
Identification Methods	affinity chromatography technology, pull down, ubiquitin reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005154 - epidermal growth factor receptor binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1308
+	Hs
		601876 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383730 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Mm
		964559 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		EGFR_MOUSE (21-1286): 0: 1089: 49.53
+	Rn
		924998 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		Q9QX70_RAT (24-1286): 0: 1074: 48.93
+	Hs
		338251 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		337418 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		872610 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB1_HUMAN (624-1002): 2.47e-122: 406: 31.65
+	Mm
		872621 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		EPHB2_MOUSE (649-989): 4.67e-119: 397: 33.89
+	Hs
		665200 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA2_HUMAN (671-1010): 7.32e-119: 396: 35.41
+	Hs
		665574 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Mm
		710138 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		FAK1_MOUSE (703-997): 3.71e-59: 224: 39.19
+	Hs
		924501 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		789054 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		924513 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Hs
		665389 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA3_HUMAN (705-987): 6.17e-54: 207: 39.10
+	Mm
		796503 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		ZAP70_MOUSE (724-967): 2.11e-55: 206: 42.45
+	Hs
		796465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ZAP70_HUMAN (724-967): 1.42e-54: 204: 41.63
+	Hs
		411352 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSR_HUMAN (353-660): 7.21e-32: 138: 19.05
+	Hs
		435602 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IGF1R_HUMAN (333-691): 3.78e-32: 138: 18.11
+	Hs
		537729 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSRR_HUMAN (351-597): 2.6e-20: 100: 16.72