HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: GARE2 (Q75VX8)
GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like)
Gene: GAREM2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.50	0.638

Property	Details
Experiments	24003223, 28514442, 33961781, 21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 874
+	Hs
		924865 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GARE1_HUMAN (4-874): 0: 651: 40.92
+	Mm
		1112482 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		GARE1_MOUSE (4-874): 0: 630: 41.58
+	Mm
		610598 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Rn
		88774 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		D3ZV15_RAT (446-859): 4.92e-22: 104: 14.76
+	Hs
		610338 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Hs
		610437 Q6ICN0_HUMAN (1-217): 3.6e-75: 227: 99.54		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (387-845): 1.27e-19: 97: 11.28
+	Mm
		610640 GRAP_MOUSE (1-213): 7.52e-66: 204: 57.67		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (383-819): 2.56e-10: 66.4: 13.68
+	Hs
		924473 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MAP1A_HUMAN (305-860): 6.5e-09: 62.3: 11.64
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (280-662): 6.77e-09: 61.9: 14.89
+	Mm
		411917 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Hs
		411595 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (387-845): 1.27e-19: 97: 11.28
+	Mm
		610555 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Mm
		610633 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Hs
		610276 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Hs
		411823 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ASPP1_HUMAN (443-809): 1.29e-09: 64.2: 10.24
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (280-662): 6.77e-09: 61.9: 14.89
+	Mm
		101430 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		F8VPR5_MOUSE (359-777): 1e-10: 68.1: 10.26