HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	31871319, 15556869
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 258
+	Hs
		924448 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		913994 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		893878 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		951449 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		925718 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		901037 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		557773 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		557724 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00
+	Hs
		789050 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		411948 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		789055 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		557649 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		545245 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		789051 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		548678 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		548672 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		411980 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		564442 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		548671 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		789092 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26