HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MED28 (Q9H204)
Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
Gene: MED28

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	15467741, 16899217
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 178
+	Hs
		411851 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		789091 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		412351 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		433471 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		442883 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		523146 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Mm
		763402 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		MED28_MOUSE (1-178): 8.45e-99: 284: 94.38