Protein: NOP15
Ribosome biogenesis protein 15 (Nucleolar protein 15)

Gene: NOP15
Organism: Saccharomyces cerevisiae S288C
Interactions: 194
UniProt ID: P53927

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

791086

NOP4
Nucleolar protein 4

4

19

High-throughput

0.892

High

924825

NOP15
Ribosome biogenesis protein 15

4

15

Small-scale

0.878

High

924309

NOP13
Nucleolar protein 13

3

19

High-throughput

0.847

High

410269

RL25
Large ribosomal subunit protein uL23

2

3

Small-scale

0.754

High

924859

NOP12
Nucleolar protein 12

2

19

High-throughput

0.754

High

918944

PESC
Pescadillo homolog

10

1

Small-scale

0.753

High

803905

CIC1
Proteasome-interacting protein CIC1

9

4

Small-scale

0.753

High

924837

HAS1
ATP-dependent RNA helicase HAS1

9

20

High-throughput

0.751

High

782401

RPF2
Ribosome biogenesis protein RPF2

8

2

Small-scale

0.748

High

816880

NUG1
Nuclear GTP-binding protein NUG1

7

8

High-throughput

0.744

High

924834

NOG1
Nucleolar GTP-binding protein 1

7

4

Small-scale

0.744

High

682357

SPB4
ATP-dependent rRNA helicase SPB4

7

20

High-throughput

0.740

High

814359

NOC2
Nucleolar complex protein 2

7

3

Small-scale

0.740

High

827575

RLP7
Ribosome biogenesis protein RLP7

6

5

Small-scale

0.737

High

818259

NSA2
Ribosome biogenesis protein NSA2

6

2

High-throughput

0.730

High

917541

NSA1
Ribosome biogenesis protein NSA1

6

1

Small-scale

0.729

High

924872

DBP10
ATP-dependent RNA helicase DBP10

6

20

High-throughput

0.729

High

924844

ERB1
Ribosome biogenesis protein ERB1

5

11

High-throughput

0.716

High

924866

YTM1
Ribosome biogenesis protein YTM1

5

20

High-throughput

0.712

High

805073

RPF1
Ribosome production factor 1

5

3

High-throughput

0.712

High

924876

IF6
Eukaryotic translation initiation factor 6

4

1

High-throughput

0.694

High

464624

PBS2
MAP kinase kinase PBS2

1

12

High-throughput

0.691

High

642440

MCK1
Protein kinase MCK1

1

9

High-throughput

0.691

High

677224

SPB1
27S pre-rRNA

4

6

High-throughput

0.691

High

746654

DRS1
ATP-dependent RNA helicase DRS1

4

20

High-throughput

0.691

High

924231

IPI3
Pre-rRNA-processing protein IPI3

4

6

High-throughput

0.691

High

924860

BRX1
Ribosome biogenesis protein BRX1

4

13

High-throughput

0.691

High

924865

MDN1
Midasin

4

2

High-throughput

0.691

High

924870

MAK21
Ribosome biogenesis protein MAK21

4

6

High-throughput

0.691

High

806640

RIX1
Pre-rRNA-processing protein RIX1

5

0

Small-scale

0.686

High

924868

NOP53
Ribosome biogenesis protein NOP53

4

3

High-throughput

0.683

High

830154

NOP2
25S rRNA

4

3

Small-scale

0.676

High

923177

NOG2
Nucleolar GTP-binding protein 2

4

8

Small-scale

0.676

High

917448

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

3

High-throughput

0.670

High

763606

UTP20
U3 small nucleolar RNA-associated protein 20

3

1

High-throughput

0.662

High

919544

SDA1
Protein SDA1

3

1

High-throughput

0.662

High

924838

ARX1
Probable metalloprotease ARX1

3

3

High-throughput

0.662

High

924855

RIX7
Ribosome biogenesis ATPase RIX7

3

11

High-throughput

0.662

High

924878

RRP12
Ribosomal RNA-processing protein 12

3

1

High-throughput

0.662

High

780297

EBP2
rRNA-processing protein EBP2

3

2

High-throughput

0.650

High

924849

JIP5
WD repeat-containing protein JIP5

3

11

High-throughput

0.650

High

924863

RRS1
Regulator of ribosome biosynthesis

3

3

High-throughput

0.650

High

924839

RRP17
Ribosomal RNA-processing protein 17

4

0

High-throughput

0.648

High

750121

MRT4
Ribosome assembly factor MRT4

3

2

Small-scale

0.640

High

763100

RRP1
Ribosomal RNA-processing protein 1

3

6

Small-scale

0.640

High

804642

SSF1
Ribosome biogenesis protein SSF1

3

3

High-throughput

0.640

High

924857

RLP24
Ribosome biogenesis protein RLP24

3

3

Small-scale

0.640

High

924858

BUD20
Bud site selection protein 20

3

0

High-throughput

0.638

High

432661

RL7A
Large ribosomal subunit protein uL30A

1

5

High-throughput

0.618

High

692602

NSR1
Nuclear localization sequence-binding protein

1

20

High-throughput

0.618

High

924835

SPP1
COMPASS component SPP1

1

4

High-throughput

0.618

High

850000

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

0

Small-scale

0.613

High

569839

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.611

High

570103

RL3
Large ribosomal subunit protein uL3

2

3

High-throughput

0.611

High

712640

RL8B
Large ribosomal subunit protein eL8B

2

5

High-throughput

0.611

High

924845

RRP5
rRNA biogenesis protein RRP5

2

12

High-throughput

0.611

High

383347

RL28
Large ribosomal subunit protein uL15

2

0

High-throughput

0.585

High

433777

RL26A
Large ribosomal subunit protein uL24A

2

3

High-throughput

0.584

High

512580

RS6A
Small ribosomal subunit protein eS6A

2

3

High-throughput

0.584

High

513396

RL23B
Large ribosomal subunit protein uL14B

2

2

Small-scale

0.584

High

513544

RL1A
Large ribosomal subunit protein uL1A

2

7

High-throughput

0.584

High

534130

MAK16
Protein MAK16

2

2

High-throughput

0.584

High

601102

RL8A
Large ribosomal subunit protein eL8A

2

5

Small-scale

0.584

High

633182

MAK11
Protein MAK11

2

20

Small-scale

0.584

High

673584

NLE1
Ribosome assembly protein 4

2

16

Small-scale

0.584

High

677514

KRR1
KRR1 small subunit processome component

2

2

High-throughput

0.584

High

793511

MAK5
ATP-dependent RNA helicase MAK5

2

20

High-throughput

0.584

High

807115

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

5

High-throughput

0.584

High

844567

UTP10
U3 small nucleolar RNA-associated protein 10

2

1

High-throughput

0.584

High

924842

PUF6
Pumilio homology domain family member 6

2

9

Small-scale

0.584

High

924848

FKBP4
FK506-binding protein 4

2

5

High-throughput

0.584

High

924850

DBP9
ATP-dependent RNA helicase DBP9

2

16

High-throughput

0.584

High

924854

NOC4
Nucleolar complex protein 4

2

6

High-throughput

0.584

High

924856

NOC3
Nucleolar complex-associated protein 3

2

4

High-throughput

0.584

High

924864

NIP7
60S ribosome subunit biogenesis protein NIP7

2

2

High-throughput

0.584

High

531837

RL4A
Large ribosomal subunit protein uL4A

2

5

High-throughput

0.571

High

803421

RL14B
Large ribosomal subunit protein eL14B

2

3

High-throughput

0.571

High

780698

RRP14
Ribosomal RNA-processing protein 14

2

0

High-throughput

0.559

High

798284

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

816782

NOP16
Nucleolar protein 16

2

0

High-throughput

0.559

High

918041

CGR1
rRNA-processing protein CGR1

2

0

Small-scale

0.559

High

924853

RRP15
Ribosomal RNA-processing protein 15

2

0

High-throughput

0.559

High

393146

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.541

High

923092

BRE5
UBP3-associated protein BRE5

1

16

High-throughput

0.536

High

924831

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

8

High-throughput

0.536

High

924836

GCN5
Histone acetyltransferase GCN5

1

17

High-throughput

0.536

High

503828

RL27A
Large ribosomal subunit protein eL27A

2

1

High-throughput

0.533

High

511257

RL20B
Large ribosomal subunit protein eL20B

2

1

High-throughput

0.533

High

753515

RS3A1
Small ribosomal subunit protein eS1A

2

1

High-throughput

0.533

High

805621

LSM12
Protein LSM12

1

2

High-throughput

0.515

High

918591

TWF1
Twinfilin-1

1

0

High-throughput

0.513

High

924861

DNLI4
DNA ligase 4

1

0

High-throughput

0.513

High

809385

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

154209

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.479

High

433261

RL17A
Large ribosomal subunit protein uL22A

1

2

High-throughput

0.479

High

434063

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.479

High

434629

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.479

High

436096

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

455197

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

503418

RL11A
Large ribosomal subunit protein uL5A

1

2

High-throughput

0.479

High

503945

RL27B
Large ribosomal subunit protein eL27B

1

1

High-throughput

0.479

High

514044

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

514173

RS16B
Small ribosomal subunit protein uS9B

1

5

High-throughput

0.479

High

515148

RL19B
Large ribosomal subunit protein eL19

1

3

High-throughput

0.479

High

515300

RL35A
Large ribosomal subunit protein uL29A

1

2

High-throughput

0.479

High

524788

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.479

High

579858

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

585337

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.479

High

637257

PWP1
Periodic tryptophan protein 1

1

16

High-throughput

0.479

High

645494

XRN1
5'-3' exoribonuclease 1

1

5

High-throughput

0.479

High

663706

RL24B
Large ribosomal subunit protein eL24B

1

3

High-throughput

0.479

High

674762

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

679941

CDC48
Cell division control protein 48

1

11

High-throughput

0.479

High

684808

RL5
Large ribosomal subunit protein uL18

1

4

High-throughput

0.479

High

689261

RL16B
Large ribosomal subunit protein uL13B

1

4

High-throughput

0.479

High

707852

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

708769

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.479

High

735096

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

738240

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

5

High-throughput

0.479

High

745100

AFG2
ATPase family gene 2 protein

1

11

High-throughput

0.479

High

747036

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

2

High-throughput

0.479

High

751455

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

3

High-throughput

0.479

High

754317

DCA13
Protein SOF1

1

12

High-throughput

0.479

High

758242

URB1
Nucleolar pre-ribosomal-associated protein 1

1

1

Small-scale

0.479

High

781239

RL14A
Large ribosomal subunit protein eL14A

1

3

High-throughput

0.479

High

782088

RL1D1
Ribosome biogenesis protein UTP30

1

3

High-throughput

0.479

High

802312

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

805007

IPI1
Pre-rRNA-processing protein IPI1

1

1

High-throughput

0.479

High

815833

BEM2
GTPase-activating protein BEM2/IPL2

1

5

High-throughput

0.479

High

816532

SNU13
13 kDa ribonucleoprotein-associated protein

1

5

High-throughput

0.479

High

820935

RL13B
Large ribosomal subunit protein eL13B

1

4

High-throughput

0.479

High

835856

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

863863

RL17B
Large ribosomal subunit protein uL22B

1

2

High-throughput

0.479

High

864495

MTR4
ATP-dependent RNA helicase DOB1

1

18

High-throughput

0.479

High

864942

NOP9
Nucleolar protein 9

1

1

High-throughput

0.479

High

865152

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

3

High-throughput

0.479

High

885047

RL4B
Large ribosomal subunit protein uL4B

1

5

High-throughput

0.479

High

918316

RL26B
Large ribosomal subunit protein uL24B

1

3

High-throughput

0.479

High

924604

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

924827

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

6

High-throughput

0.479

High

924828

RCM1
25S rRNA

1

3

High-throughput

0.479

High

924829

ORC1
Origin recognition complex subunit 1

1

9

High-throughput

0.479

High

924830

ACT
Actin

1

9

High-throughput

0.479

High

924832

RL6A
Large ribosomal subunit protein eL6A

1

3

High-throughput

0.479

High

924833

XRN2
5'-3' exoribonuclease 2

1

5

High-throughput

0.479

High

924840

DHR1
Probable ATP-dependent RNA helicase DHR1

1

6

High-throughput

0.479

High

924841

RRB1
Ribosome assembly protein RRB1

1

8

High-throughput

0.479

High

924843

UTP14
U3 small nucleolar RNA-associated protein 14

1

4

High-throughput

0.479

High

924852

RRP9
Ribosomal RNA-processing protein 9

1

20

High-throughput

0.479

High

924867

FCF2
rRNA-processing protein FCF2

1

1

High-throughput

0.479

High

924869

SSF2
Ribosome biogenesis protein SSF2

1

3

High-throughput

0.479

High

924873

NOP56
Nucleolar protein 56

1

7

High-throughput

0.479

High

924874

NOP58
Nucleolar protein 58

1

7

High-throughput

0.479

High

924875

CMR1
DNA damage-binding protein CMR1

1

11

High-throughput

0.479

High

924877

RL13A
Large ribosomal subunit protein eL13A

1

4

High-throughput

0.479

High

924881

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

924871

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.460

High

442048

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

477606

MYO1
Myosin-1

1

0

High-throughput

0.458

High

514768

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

689592

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

700272

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.458

High

778471

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

795835

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

804119

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

High-throughput

0.458

High

808878

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

818327

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

825391

BMT5
25S rRNA

1

0

High-throughput

0.458

High

826725

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

836194

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.458

High

864181

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.458

High

879875

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

916855

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.458

High

924826

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

924846

RSA3
Ribosome assembly protein 3

1

0

High-throughput

0.458

High

924847

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

924851

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

924862

SGO1
Shugoshin

1

0

High-throughput

0.458

High

924880

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

High-throughput

0.458

High

924882

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

394794

EF1A
Elongation factor 1-alpha

1

8

High-throughput

0.445

High

453732

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

545840

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

504350

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

504546

RL31B
Large ribosomal subunit protein eL31B

1

3

High-throughput

0.437

High

511465

RL43B
Large ribosomal subunit protein eL43B

1

1

Small-scale

0.437

High

511836

RS24A
Small ribosomal subunit protein eS24A

1

1

High-throughput

0.437

High

513147

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

514337

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.437

High

747510

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

812547

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

918420

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

924879

RS28A
Small ribosomal subunit protein eS28A

1

1

High-throughput

0.437

High


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Last updated: 11Aug2025