HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	28514442, 33961781, 21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 1746
+	Mm
		1141136 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PEAK1_MOUSE (1-1746): 0: 2159: 85.76
+	Hs
		411858 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		782826 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		434012 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Mm
		411915 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12
+	Hs
		681710 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		883142 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		HUNK_HUMAN (1405-1659): 1.25e-44: 176: 20.61
+	Hs
		681838 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Mm
		403411 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12
+	Hs
		412046 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		411994 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		522810 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		924654 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46
+	Hs
		924680 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRAG1_HUMAN (1-91): 6.17e-28: 125: 40.43
+	Mm
		782849 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		PRAG1_MOUSE (1-91): 5.76e-34: 145: 38.04
+	Hs
		433578 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Hs
		522780 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Hs
		782802 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		PRAG1_HUMAN (1-91): 6.17e-28: 125: 40.43