Protein: TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)

Gene: TDIF2, DNTTIP2
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q5QJE6

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005730 - nucleolus
GO:0006396 - RNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1208808

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

1

High-throughput

0.656

High

372229

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

1208770

CAVN1
Caveolae-associated protein 1

3

0

High-throughput

0.625

High

447093

NPM
Nucleophosmin

3

0

High-throughput

0.622

High

979784

H4
Histone H4

3

0

Small-scale

0.619

High

485189

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

1

High-throughput

0.611

High

978986

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.611

High

1208788

ESR2
Estrogen receptor beta

2

2

Small-scale

0.595

High

1161482

IF16
Gamma-interferon-inducible protein 16

2

0

High-throughput

0.585

High

980826

H2B1C
Histone H2B type 1-C/E/F/G/I

2

2

High-throughput

0.584

High

998406

H31
Histone H3.1

2

3

High-throughput

0.584

High

1016918

H33
Histone H3.3

2

3

High-throughput

0.584

High

302549

RNF8
E3 ubiquitin-protein ligase RNF8

2

0

High-throughput

0.580

High

396273

ESR1
Estrogen receptor

1

3

Small-scale

0.573

High

643880

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.559

High

810148

RL3
Large ribosomal subunit protein uL3

2

0

High-throughput

0.547

High

74511

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.536

High

658220

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

860227

RS9
Small ribosomal subunit protein uS4

1

2

High-throughput

0.536

High

1008760

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.536

High

1162965

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1208799

RBM4B
RNA-binding protein 4B

1

1

High-throughput

0.536

High

1208806

RBM4
RNA-binding protein 4

1

1

High-throughput

0.536

High

1208823

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

279387

TULP3
Tubby-related protein 3

1

0

High-throughput

0.518

High

488125

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

1

High-throughput

0.515

High

1208811

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.515

High

596140

H12
Histone H1.2

1

0

High-throughput

0.513

High

785215

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

824181

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

854100

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

859855

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

948537

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1142787

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.513

High

1208787

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

1208824

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

1208827

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

402307

TDT
DNA nucleotidylexotransferase

1

0

Small-scale

0.504

High

625829

RXRA
Retinoic acid receptor RXR-alpha

1

2

Small-scale

0.501

High

789512

PPARG
Peroxisome proliferator-activated receptor gamma

1

3

Small-scale

0.501

High

1208773

H32
Histone H3.2

1

3

Small-scale

0.501

High

1208792

H2B1A
Histone H2B type 1-A

1

2

Small-scale

0.501

High

1005461

RBM6
RNA-binding protein 6

1

0

High-throughput

0.493

High

1125758

FA50A
Protein FAM50A

1

0

High-throughput

0.493

High

1208803

H2AJ
Histone H2A.J

1

1

High-throughput

0.489

High

140953

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

260055

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

345914

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

385822

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

406259

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

462456

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.479

High

487394

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

674194

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

714174

PML
Protein PML

1

1

High-throughput

0.479

High

879169

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

883566

CENPA
Histone H3-like centromeric protein A

1

3

High-throughput

0.479

High

1032177

EXOSX
Exosome complex component 10

1

1

High-throughput

0.479

High

1137755

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1208781

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1208783

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

1208786

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1208810

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.479

High

1208814

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1208791

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

129156

MEN1
Menin

1

0

High-throughput

0.458

High

190942

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

223110

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

247954

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

274614

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

284161

SRS10
Serine/arginine-rich splicing factor 10

1

0

Small-scale

0.458

High

558186

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

588867

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

606842

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

695646

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

697139

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

768369

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

903178

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

High-throughput

0.458

High

915454

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.458

High

920016

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

937776

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

966421

1433G
14-3-3 protein gamma

1

0

High-throughput

0.458

High

982692

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

984800

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1004669

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1045371

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1097332

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1106939

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1125125

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

1138291

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1208777

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1208778

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1208785

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1208790

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.458

High

1208794

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1208796

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1208804

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

0

High-throughput

0.458

High

1208805

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1208813

ANLN
Anillin

1

0

High-throughput

0.458

High

1208819

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1208820

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1208826

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1208828

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1208774

H2A3
Histone H2A type 3

1

1

Small-scale

0.457

High

860778

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.445

High

1208801

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.445

High

1208812

EXOS4
Exosome complex component RRP41

1

2

High-throughput

0.445

High

1141160

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.437

High

1208771

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1208822

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

442740

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

601712

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

904814

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.426

High

1006453

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.426

High

1130294

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1208779

YAF2
YY1-associated factor 2

1

0

High-throughput

0.426

High

1208782

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.426

High

1208800

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

1208816

RBM28
RNA-binding protein 28

1

0

High-throughput

0.426

High

1208784

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1208815

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

169186

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

191666

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.279

Low

483114

CLCA
Clathrin light chain A

1

0

High-throughput

0.279

Low

488055

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

546977

FGF3
Fibroblast growth factor 3

1

0

High-throughput

0.279

Low

657250

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

1016338

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.279

Low

1092767

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1163576

RTN1
Reticulon-1

1

0

High-throughput

0.279

Low

1208769

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1208776

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

1208793

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1208795

HDA11
Histone deacetylase 11

1

0

High-throughput

0.279

Low

1208798

TECTB
Beta-tectorin

1

0

High-throughput

0.279

Low

1208802

ZNF2
Zinc finger protein 2

1

0

High-throughput

0.279

Low

1208818

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

1208825

KLH20
Kelch-like protein 20

1

0

High-throughput

0.279

Low

1208829

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

522272

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

157469

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

272243

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

445196

S10A6
Protein S100-A6

1

0

High-throughput

0.249

Low

942670

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

1140389

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1208772

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

1208775

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1208789

NELL1
Protein kinase C-binding protein NELL1

1

0

Small-scale

0.249

Low

1208797

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.249

Low

1208807

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1208809

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1208817

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.249

Low

1063958

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.232

Low

1132373

CASP8
Caspase-8

1

0

High-throughput

0.232

Low

1208780

RNF10
E3 ubiquitin-protein ligase RNF10

1

0

High-throughput

0.232

Low

1208821

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025