HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: LIMA1 (Q9UHB6)
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Gene: LIMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 759
+	Hs
		433500 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		924720 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MICA1_HUMAN (333-572): 7.65e-38: 154: 20.00
+	Hs
		597760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CSRP1_HUMAN (254-449): 3.7e-34: 131: 15.82
+	Hs
		150552 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		823365 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		337510 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MICA1_HUMAN (333-572): 7.65e-38: 154: 20.00
+	Hs
		411641 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		200163 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		TGFI1_HUMAN (263-447): 1.47e-16: 85: 15.64
+	Hs
		150515 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		150611 Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		782755 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		557639 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		337395 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Mm
		337635 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		PAXI_MOUSE (268-446): 9.35e-14: 76.9: 14.53
+	Hs
		789046 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Dm
		337656 ABL_DROME (4-135): 1e-22: 97.4: 37.68		MICAL_DROME (371-515): 6.96e-12: 71.8: 24.83
+	Hs
		412085 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		433288 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		442793 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		433354 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		LASP1_HUMAN (390-480): 2.66e-11: 66.8: 25.00