HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0048026 - positive regulation of mRNA splicing, via spliceosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 288 Hs			1 282
+	Hs
		1040399 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		925007 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		964080 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1347098 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		925150 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		1020321 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		1020251 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		1031314 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		1020338 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		925019 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516502 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Ce
		1353617 Q9U2S6_CAEEL (118-203): 1.61e-24: 102: 35.56		Q9U2S6_CAEEL (9-102): 1.18e-30: 118: 28.72
+	Hs
		516451 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Mm
		857303 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Hs
		1020353 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516744 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Xl
		1265032 ELAV2_XENLA (11-250): 1.45e-22: 98: 17.28		ELAV2_XENLA (10-92): 8.97e-24: 100: 25.00
+	Hs
		1020249 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516484 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63