HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: TBB3 (Q13509)
Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)
Gene: TUBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0030027 - lamellipodium and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 450
+	Hs
		893979 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		TBB3_HUMAN (1-450): 0: 723: 100.00
+	Rn
		1109026 RAC1_RAT (1-192): 3.81e-86: 253: 100.00		TBB2B_RAT (1-430): 0: 703: 93.72
+	Hs
		1046579 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		TBB2A_HUMAN (1-430): 0: 700: 93.49
+	Hs
		428118 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		893889 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		TBB4B_HUMAN (1-427): 0: 703: 93.91
+	Hs
		950983 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		TBB2A_HUMAN (1-430): 0: 700: 93.49
+	Hs
		428120 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		381156 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		TBB4A_HUMAN (1-427): 0: 699: 93.21
+	Bt
		900343 RHOA_BOVIN (5-192): 3.5e-77: 230: 57.98		TBB2B_BOVIN (1-430): 0: 703: 93.72
+	Hs
		900366 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		TBB4B_HUMAN (1-427): 0: 703: 93.91
+	Hs
		900852 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		TBB6_HUMAN (1-446): 0: 700: 92.38