HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	19961560, 15306850, 31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030027 - lamellipodium GO:0030032 - lamellipodium assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 776
+	Hs
		564535 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG6_HUMAN (1-776): 0: 621: 100.00
+	Gg
		1141019 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		ARHG6_CHICK (1-775): 0: 589: 73.55
+	Hs
		925271 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		564524 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		925718 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03
+	Hs
		548678 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV_HUMAN (1-746): 1.59e-120: 384: 16.20
+	Hs
		855782 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV2_HUMAN (1-746): 1.37e-111: 361: 15.14
+	Hs
		925527 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPT13_HUMAN (100-638): 8.39e-103: 332: 17.54
+	Hs
		925649 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG4_HUMAN (158-638): 2e-93: 308: 20.75
+	Hs
		925382 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX2_HUMAN (220-543): 5.59e-83: 291: 21.39
+	Hs
		925455 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX1_HUMAN (218-552): 8.7e-83: 291: 23.40
+	Hs
		925622 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG2_HUMAN (201-750): 2.66e-83: 291: 19.47
+	Ce
		975575 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		VAV_CAEEL (2-724): 3.34e-86: 295: 15.59
+	Hs
		50580 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		50555 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		925727 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG1_HUMAN (179-720): 1.21e-80: 284: 19.53
+	Hs
		564737 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHG1_HUMAN (179-720): 1.21e-80: 284: 19.53
+	Hs
		925405 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGP_HUMAN (218-656): 3.19e-79: 267: 18.87
+	Hs
		224711 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KALRN_HUMAN (203-772): 1.73e-74: 266: 17.83
+	Hs
		279854 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TRIO_HUMAN (230-567): 1.42e-72: 261: 20.46