HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: RSU1 (Q15404)
Ras suppressor protein 1 (RSP-1) (Rsu-1)
Gene: RSU1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0010811 - positive regulation of cell-substrate adhesion GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 277
+	Dm
		776906 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q9V428_DROME (1-269): 3.14e-57: 186: 58.15
+	Hs
		925539 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ERBIN_HUMAN (3-247): 5.27e-46: 167: 27.64
+	Dm
		776889 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		SCRIB_DROME (3-217): 1.62e-48: 174: 32.49
+	Hs
		564652 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ERBIN_HUMAN (3-247): 5.27e-46: 167: 27.64
+	Hs
		925273 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SCRIB_HUMAN (3-217): 2.54e-43: 159: 29.71
+	Hs
		545571 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ERBIN_HUMAN (3-247): 5.27e-46: 167: 27.64
+	Hs
		564526 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		SCRIB_HUMAN (3-217): 2.54e-43: 159: 29.71
+	Hs
		1301445 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ERBIN_HUMAN (3-247): 5.27e-46: 167: 27.64
+	Hs
		545370 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		SCRIB_HUMAN (3-217): 2.54e-43: 159: 29.71
+	Hs
		951251 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ERBIN_HUMAN (3-247): 5.27e-46: 167: 27.64
+	Hs
		1050061 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		SCRIB_HUMAN (3-217): 2.54e-43: 159: 29.71
+	Hs
		892367 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		SCRIB_HUMAN (3-217): 2.54e-43: 159: 29.71
+	Hs
		950989 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		SCRIB_HUMAN (3-217): 2.54e-43: 159: 29.71
+	Hs
		925519 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		LRCH3_HUMAN (2-106): 5.1e-16: 79.5: 25.47
+	Hs
		925419 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		LRC8A_HUMAN (64-250): 2.89e-11: 65.6: 23.59
+	Hs
		564604 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		LRC8A_HUMAN (64-250): 2.89e-11: 65.6: 23.59
+	Hs
		545486 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		LRC8A_HUMAN (64-250): 2.89e-11: 65.6: 23.59
+	Hs
		1219415 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		LRC8A_HUMAN (64-250): 2.89e-11: 65.6: 23.59
+	Hs
		892474 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		LRC8A_HUMAN (64-250): 2.89e-11: 65.6: 23.59
+	Hs
		951139 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		LRC8A_HUMAN (64-250): 2.89e-11: 65.6: 23.59